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Dendritic Cell-Based Approaches for Therapeutic Immune Regulation in Solid-Organ Transplantation
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-24
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
To avoid immune rejection, allograft recipients require drug-based immunosuppression, which has significant toxicity.
An emerging approach is adoptive transfer of immunoregulatory cells.
While mature dendritic cells (DCs) present donor antigen to the immune system, triggering rejection, regulatory DCs interact with regulatory T cells to promote immune tolerance.
Intravenous injection of immature DCs of either donor or host origin at the time of transplantation have prolonged allograft survival in solid-organ transplant models.
DCs can be treated with pharmacological agents before injection, which may attenuate their maturation in vivo.
Recent data suggest that injected immunosuppressive DCs may inhibit allograft rejection, not by themselves, but through conventional DCs of the host.
Genetically engineered DCs have also been tested.
Two clinical trials in type-1 diabetes and rheumatoid arthritis have been carried out, and other trials, including one trial in kidney transplantation, are in progress or are imminent.
American Psychological Association (APA)
Vassalli, Giuseppe. 2013. Dendritic Cell-Based Approaches for Therapeutic Immune Regulation in Solid-Organ Transplantation. Journal of Transplantation،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-496697
Modern Language Association (MLA)
Vassalli, Giuseppe. Dendritic Cell-Based Approaches for Therapeutic Immune Regulation in Solid-Organ Transplantation. Journal of Transplantation No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-496697
American Medical Association (AMA)
Vassalli, Giuseppe. Dendritic Cell-Based Approaches for Therapeutic Immune Regulation in Solid-Organ Transplantation. Journal of Transplantation. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-496697
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496697