The Use of Epidermal Growth Factor Receptor Monoclonal Antibodies in Squamous Cell Carcinoma of the Head and Neck
Joint Authors
Colevas, A. Dimitrios
Russell, Jeffery S.
Source
Chemotherapy Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Targeting of the EGF receptor (EGFR) has become a standard of care in several tumor types.
In squamous cell carcinoma of the head and neck, monoclonal antibodies directed against EGFR have become a regular component of therapy for curative as well as palliative treatment strategies.
These agents have anti-tumor efficacy as a single modality and have demonstrated synergistic tumor killing when combined with radiation and/or chemotherapy.
While cetuximab has been the primary anti-EGFR monoclonal antibody used in the US, variant anti-EGFR monoclonal antibodies have been used in several clinical studies and shown benefit with improved toxicity profiles.
Next generation anti-EGFR monoclonal antibodies may demonstrate multi-target epitope recognition, enhanced immune cell stimulation, or conjugation with radioisotopes in order to improve clinical outcomes.
Identification of the specific patient subset that would optimally benefit from anti-EGFR monoclonal antibodies remains an elusive goal.
American Psychological Association (APA)
Russell, Jeffery S.& Colevas, A. Dimitrios. 2012. The Use of Epidermal Growth Factor Receptor Monoclonal Antibodies in Squamous Cell Carcinoma of the Head and Neck. Chemotherapy Research and Practice،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-496707
Modern Language Association (MLA)
Russell, Jeffery S.& Colevas, A. Dimitrios. The Use of Epidermal Growth Factor Receptor Monoclonal Antibodies in Squamous Cell Carcinoma of the Head and Neck. Chemotherapy Research and Practice No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-496707
American Medical Association (AMA)
Russell, Jeffery S.& Colevas, A. Dimitrios. The Use of Epidermal Growth Factor Receptor Monoclonal Antibodies in Squamous Cell Carcinoma of the Head and Neck. Chemotherapy Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-496707
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496707