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Collagen-Based Films Containing Liposome-Loaded Usnic Acid as Dressing for Dermal Burn Healing
Joint Authors
Souza, Jamille C. C.
Dantas, Marx D. M.
Quitans-Jr, Lucindo J.
Bonjardim, Leonardo R.
Serafini, Mairim Russo
Araújo, Adriano A. S.
de Albuquerque Junior, Ricardo Luiz Cavalcanti
Bezerra, Marília S.
Cavalcante, Danielle R. R.
Nunes, Paula S.
Cardoso, Juliana C.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of this study was assess the effect of collagen-based films containing usnic acid as a wound dressing for dermal burn healing.
Second-degree burn wounds were performed in forty-five Wistar rats, assigned into nine groups: COL—animals treated with collagen-based films; PHO—animals treated with collagen films containing empty liposomes; UAL—animals treated with collagen-based films containing usnic acid incorporated into liposomes.
After 7, 14, and 21 days the animals were euthanized.
On 7th day there was a moderate infiltration of neutrophils, in UAL, distributed throughout the burn wounds, whereas in COL and PHO, the severity of the reaction was slighter and still limited to the margins of the burn wounds.
On the 14th day, the inflammatory reaction was less intense in UAL, with remarkable plasma cells infiltration.
On the 21st day, there was reduction of the inflammation, which was predominantly composed of plasma cells in all groups, particularly in UAL.
The use of the usnic acid provided more rapid substitution of type-III for type-I collagen on the 14th day, and improved the collagenization density on the 21st day.
It was concluded that the use of reconstituted bovine type-I collagen-based films containing usnic acid improved burn healing process in rats.
American Psychological Association (APA)
Nunes, Paula S.& de Albuquerque Junior, Ricardo Luiz Cavalcanti& Cavalcante, Danielle R. R.& Dantas, Marx D. M.& Cardoso, Juliana C.& Bezerra, Marília S.…[et al.]. 2011. Collagen-Based Films Containing Liposome-Loaded Usnic Acid as Dressing for Dermal Burn Healing. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-496718
Modern Language Association (MLA)
Nunes, Paula S.…[et al.]. Collagen-Based Films Containing Liposome-Loaded Usnic Acid as Dressing for Dermal Burn Healing. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-496718
American Medical Association (AMA)
Nunes, Paula S.& de Albuquerque Junior, Ricardo Luiz Cavalcanti& Cavalcante, Danielle R. R.& Dantas, Marx D. M.& Cardoso, Juliana C.& Bezerra, Marília S.…[et al.]. Collagen-Based Films Containing Liposome-Loaded Usnic Acid as Dressing for Dermal Burn Healing. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-496718
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496718