![](/images/graphics-bg.png)
Protective Effects of Aspirin from Cardiac Hypertrophy and Oxidative Stress in Cardiomyopathic Hamsters
Joint Authors
Girouard, Helene
Sadekova, Nataliya
Deschepper, Christian F.
Yin, David
Wu, Rong
de Champlain, Jacques
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Objective.
To evaluate the capacity of chronic ASA therapy to prevent cardiac alterations and increased oxidative stress in cardiomyopathic hamsters.
Methods and Results.
Male Syrian cardiomyopathic and age-matched inbred control hamsters received ASA orally from the age of 60 days.
Animals were sacrificed at the age of 150, 250, and 350 days to evaluate the time course of cardiac hypertrophy and cardiovascular tissue superoxide anion (O2-) production.
At the age of 150 days, the ventricular weight over body weight ratio, resting heart rate, and cardiovascular O2- production were much higher in cardiomyopathic hamsters than those in control.
At the age of 250 days, in addition to the continual deterioration of these parameters with age, the blood pressure started to fall and the signs of heart failure appeared.
In these cardiomyopathic hamsters, chronic ASA treatment (a) completely prevented elevated O2- production and the NAD(P)H oxidase activity, (b) significantly slowed down the development of the cardiac hypertrophy and fibrosis.
Conclusions.
Chronic ASA treatment significantly prevents the deterioration of cardiac function and structure as well as the increased oxidative stress in the cardiomyopathic hamster.
Our findings suggest that ASA presents a therapeutic potential to prevent cardiac dysfunction.
American Psychological Association (APA)
Wu, Rong& Yin, David& Sadekova, Nataliya& Deschepper, Christian F.& de Champlain, Jacques& Girouard, Helene. 2012. Protective Effects of Aspirin from Cardiac Hypertrophy and Oxidative Stress in Cardiomyopathic Hamsters. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-496726
Modern Language Association (MLA)
Wu, Rong…[et al.]. Protective Effects of Aspirin from Cardiac Hypertrophy and Oxidative Stress in Cardiomyopathic Hamsters. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-496726
American Medical Association (AMA)
Wu, Rong& Yin, David& Sadekova, Nataliya& Deschepper, Christian F.& de Champlain, Jacques& Girouard, Helene. Protective Effects of Aspirin from Cardiac Hypertrophy and Oxidative Stress in Cardiomyopathic Hamsters. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-496726
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496726