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Genetic Aspects of Gastric Cancer Instability
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Unravelling the molecular mechanisms underlying gastric carcinogenesis is one of the major challenges in cancer genomics.
Gastric cancer is a very complex and heterogeneous disease, and although much has been learned about the different genetic changes that eventually lead to its development, the detailed mechanisms still remain unclear.
Malignant transformation of gastric cells is the consequence of a multistep process involving different genetic and epigenetic changes in numerous genes in combination with host genetic background and environmental factors.
The majority of gastric adenocarcinomas are characterized by genetic instability, either microsatellite instability (MSI) or chromosomal instability (CIN).
It is believed that chromosome destabilizations occur early in tumour progression.
This paper summarizes the most common genetic alterations leading to instability in sporadic gastric cancers and its consequences.
American Psychological Association (APA)
Hudler, Petra. 2012. Genetic Aspects of Gastric Cancer Instability. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-496745
Modern Language Association (MLA)
Hudler, Petra. Genetic Aspects of Gastric Cancer Instability. The Scientific World Journal No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-496745
American Medical Association (AMA)
Hudler, Petra. Genetic Aspects of Gastric Cancer Instability. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-496745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496745