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Potential Antidepressant Role of Neurotransmitter CART : Implications for Mental Disorders
Author
Source
Depression Research and Treatment
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Depression is one of the most prevalent and debilitating public health concerns.
Although no single cause of depression has been identified, it appears that interaction among genetic, epigenetic, biochemical, environmental, and psychosocial factors may explain its etiology.
Further, only a fraction of depressed patients show full remission while using current antidepressants.
Therefore, identifying common pathways of the disorder and using that knowledge to develop more effective pharmacological treatments are two primary targets of research in this field.
Brain-enriched neurotransmitter CART (cocaine- and amphetamine-regulated transcript) has multiple functions related to emotions.
It is a potential neurotrophic factor and is involved in the regulation of hypothalamic-pituitary-adrenal axis and stress response as well as in energy homeostasis.
CART is also highly expressed in limbic system, which is considered to have an important role in regulating mood.
Notably, adolescents carrying a missense mutation in the CART gene exhibit increased depression and anxiety.
Hence, CART peptide may be a novel promising antidepressant agent.
In this paper, we summarize recent progress in depression and CART.
In particular, we emphasize a new antidepressant function for CART.
American Psychological Association (APA)
Mao, Peizhong. 2011. Potential Antidepressant Role of Neurotransmitter CART : Implications for Mental Disorders. Depression Research and Treatment،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-496771
Modern Language Association (MLA)
Mao, Peizhong. Potential Antidepressant Role of Neurotransmitter CART : Implications for Mental Disorders. Depression Research and Treatment No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-496771
American Medical Association (AMA)
Mao, Peizhong. Potential Antidepressant Role of Neurotransmitter CART : Implications for Mental Disorders. Depression Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-496771
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496771