Genetic Association between Akt1 Polymorphisms and Alzheimer's Disease in a Japanese Population
Joint Authors
Komatsu, Miwa
Arai, Heii
Shibata, Nobuto
Ohnuma, Tohru
Kuerban, Bolati
Baba, Hajime
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-14
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A recent paper reported that Aβ oligomer causes neuronal cell death through the phosphatidylinositol-3-OH kinase (PI3K)-Akt-mTOR signaling pathway.
Intraneuronal Aβ, a main pathological finding of Alzheimer's disease (AD), is also known as inhibiting activation of Akt.
This study aims to investigate whether single nucleotide polymorphisms (SNPs) of the Akt1 gene are associated with AD.
SNPs genotyped using TaqMan technology was analyzed using a case-control study design.
Our case-control dataset consisted of 180 AD patients and 130 age-matched controls.
Although two SNPs showed superficial positive, Hardy-Weinberg equilibrium (HWE) tests, and linkage disequilibrium (LD) analyses suggested that genetic regions of the gene are highly polymorphic.
We failed to detect any synergetic association among Akt1 polymorphisms, Apolipoprotein E (APO E), and AD.
Further genetic studies are needed to clarify the relationship between the Akt1 and AD.
American Psychological Association (APA)
Shibata, Nobuto& Ohnuma, Tohru& Kuerban, Bolati& Komatsu, Miwa& Baba, Hajime& Arai, Heii. 2011. Genetic Association between Akt1 Polymorphisms and Alzheimer's Disease in a Japanese Population. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-496788
Modern Language Association (MLA)
Shibata, Nobuto…[et al.]. Genetic Association between Akt1 Polymorphisms and Alzheimer's Disease in a Japanese Population. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-496788
American Medical Association (AMA)
Shibata, Nobuto& Ohnuma, Tohru& Kuerban, Bolati& Komatsu, Miwa& Baba, Hajime& Arai, Heii. Genetic Association between Akt1 Polymorphisms and Alzheimer's Disease in a Japanese Population. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-496788
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496788