In Vitro Screening for β-Hydroxy-β-methylglutaryl-CoA Reductase Inhibitory and Antioxidant Activity of Sequentially Extracted Fractions of Ficus palmata Forsk
Joint Authors
Ahmad, Saheem
Iqbal, Danish
Khan, Mohd. Sajid
Khan, M. Salman
Bagga, Paramdeep
Khan, Amir
Srivastava, Ashwani K.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hypercholesterolemia-induced oxidative stress has been strongly implicated in the pathogenesis of atherosclerosis, which is one of the major causes of mortality worldwide.
The current work, for the first time, accounts the antioxidant, genoprotective, antilipoperoxidative, and HMG-CoA reductase (EC 1.1.1.34) inhibitory properties of traditional medicinal plant, Ficus palmata Forsk.
Our result showed that among sequentially extracted fractions of Ficus palmata Forsk, FPBA (F.
palmata bark aqueous extract) and FPLM (F.
palmata leaves methanolic extract) extracts have higher phenolic content and also exhibited significantly more radical scavenging (DPPH and Superoxide) and antioxidant (FRAP) capacity.
Moreover, FPBA extract also exhibited significantly higher inhibition of lipid peroxidation assay.
Additionally, results showed almost complete and partial protection of oxidatively damaged DNA by these plant extracts when compared to mannitol.
Furthermore, our results showed that FPBA extract (IC50=9.1±0.61 µg/mL) exhibited noteworthy inhibition of HMG-CoA reductase activity as compared to other extracts, which might suggest its role as cardioprotective agent.
In conclusion, results showed that FPBA extract not only possess significant antioxidant and genoprotective property but also is able to attenuate the enzymatic activity of HMG-CoA reductase, which might suggest its role in combating various oxidative stress-related diseases, including atherosclerosis.
American Psychological Association (APA)
Iqbal, Danish& Khan, M. Salman& Khan, Amir& Khan, Mohd. Sajid& Ahmad, Saheem& Srivastava, Ashwani K.…[et al.]. 2014. In Vitro Screening for β-Hydroxy-β-methylglutaryl-CoA Reductase Inhibitory and Antioxidant Activity of Sequentially Extracted Fractions of Ficus palmata Forsk. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-496805
Modern Language Association (MLA)
Iqbal, Danish…[et al.]. In Vitro Screening for β-Hydroxy-β-methylglutaryl-CoA Reductase Inhibitory and Antioxidant Activity of Sequentially Extracted Fractions of Ficus palmata Forsk. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-496805
American Medical Association (AMA)
Iqbal, Danish& Khan, M. Salman& Khan, Amir& Khan, Mohd. Sajid& Ahmad, Saheem& Srivastava, Ashwani K.…[et al.]. In Vitro Screening for β-Hydroxy-β-methylglutaryl-CoA Reductase Inhibitory and Antioxidant Activity of Sequentially Extracted Fractions of Ficus palmata Forsk. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-496805
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496805