Population Pharmacokinetics of Vancomycin in Thai Patients

Abstract EN

Population pharmacokinetics of vancomycin in Thai adult patients was determined by non-linear mixed-effects approach using 319 vancomycin serum concentrations from 212 patients.

The data were best fitted by a two-compartment model and it was used to examine the effect of patient characteristics on the vancomycin pharmacokinetics.

In the final model, there was a linear relationship between vancomycin clearance, CL (L/h), and creatinine clearance calculated by Cockcroft-Gault equation, CLCr (mL/min): CL =0.044 × CLCr.

Meanwhile, volume of central compartment, V1 (L), was linearly related with the age (years old): V1=0.542 × Age.

Intercompartment clearance (Q) and volume of peripheral compartment (V2) was 6.95 L/h and 44.2 L, respectively.

The interindividual variability for CL, V1, Q, and V2 was 35.78, 20.93, 39.50, and 57.27%, respectively.

Whereas, the intraindividual variability was 4.51 mg/L.

Final model then was applied to predict serum vancomycin concentrations on validation group.

Predictive performance revealed a bias of −1.43 mg/L (95% CI: −5.82–2.99) and a precision of 12.2 mg/L (95% CI: −1.60–26.16).

In conclusion, population pharmacokinetic of vancomycin in Thai adult patients was developed.

The model could be used to create vancomycin dosage regimen in the type of patient similar with the present study.