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Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming : A Diabolic Liaison
Joint Authors
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Conversely to normal cells, where deregulated oxidative stress drives the activation of death pathways, malignant cells exploit oxidative milieu for its advantage.
Cancer cells are located in a very complex microenvironment together with stromal components that participate to enhance oxidative stress to promote tumor progression.
Indeed, convincing experimental and clinical evidence underline the key role of oxidative stress in several tumor aspects thus affecting several characteristics of cancer cells.
Oxidants influence the DNA mutational potential, intracellular signaling pathways controlling cell proliferation and survival and cell motility and invasiveness as well as control the reactivity of stromal components that is fundamental for cancer development and dissemination, inflammation, tissue repair, and de novo angiogenesis.
This paper is focused on the role of oxidant species in the acquisition of two mandatory features for aggressive neoplastic cells, recently defined by Hanahan and Weinberg as new “hallmarks of cancer”: tumor microenvironment and metabolic reprogramming of cancer cells.
American Psychological Association (APA)
Fiaschi, Tania& Chiarugi, Paola. 2012. Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming : A Diabolic Liaison. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-496829
Modern Language Association (MLA)
Fiaschi, Tania& Chiarugi, Paola. Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming : A Diabolic Liaison. International Journal of Cell Biology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-496829
American Medical Association (AMA)
Fiaschi, Tania& Chiarugi, Paola. Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming : A Diabolic Liaison. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-496829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496829