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Hypoxia-Inducible Factor in Thyroid Carcinoma
Joint Authors
Burrows, Natalie
Resch, Julia
Babur, Muhammad
Brabant, Georg
Williams, Kaye J.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor prognosis.
Hypoxia-inducible factor-1 is a transcription factor activated by hypoxia that regulates the expression of genes that promote tumour cell survival, progression, metastasis, and resistance to chemo/radiotherapy.
In addition to hypoxia, HIF-1 can be activated by growth factor-signalling pathways such as the mitogen-activated protein kinases- (MAPK-) and phosphatidylinositol-3-OH kinases- (PI3K-) signalling cascades.
Mutations in these pathways are common in thyroid carcinoma and lead to enhanced HIF-1 expression and activity.
Here, we summarise current data that highlights the potential role of both hypoxia and MAPK/PI3K-induced HIF-1 signalling in thyroid carcinoma progression, metastatic characteristics, and the potential role of HIF-1 in thyroid carcinoma response to radiotherapy.
Direct or indirect targeting of HIF-1 using an MAPK or PI3K inhibitor in combination with radiotherapy may be a new potential therapeutic target to improve the therapeutic response of thyroid carcinoma to radiotherapy and reduce metastatic burden.
American Psychological Association (APA)
Burrows, Natalie& Babur, Muhammad& Resch, Julia& Williams, Kaye J.& Brabant, Georg. 2011. Hypoxia-Inducible Factor in Thyroid Carcinoma. Journal of Thyroid Research،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-496835
Modern Language Association (MLA)
Burrows, Natalie…[et al.]. Hypoxia-Inducible Factor in Thyroid Carcinoma. Journal of Thyroid Research No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-496835
American Medical Association (AMA)
Burrows, Natalie& Babur, Muhammad& Resch, Julia& Williams, Kaye J.& Brabant, Georg. Hypoxia-Inducible Factor in Thyroid Carcinoma. Journal of Thyroid Research. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-496835
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496835