Flow Cytometry in the Detection of Neonatal Sepsis
Joint Authors
Dreschers, Stephan
Orlikowsky, Thorsten W.
Umlauf, Volker N.
Source
International Journal of Pediatrics
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Neonatal sepsis remains a burden problem by showing minimal initial symptoms of subtle character, nonspecific manifestation, and diagnostic pitfalls.
The clinical course can be fulminant and fatal if treatment is not commenced promptly.
It is therefore crucial to establish early diagnosis and initiate adequate therapy.
Besides clinical symptoms, the most reliable laboratory markers in establishing diagnosis is currently the combined measurement of CRP and a cytokine (IL-6 and IL-8).
Due to their different kinetics, a diagnostic gap might occur and thus withholding antimicrobial therapy in clinical suspicion of infection is not acceptable.
We therefore need parameters which unerringly differentiate between infants in need for antimicrobial therapy and those who are not.
Flow cytometry promises to be a useful tool in this field, allowing the determination of different cellular, dissolved, and functional pathophysiological components of sepsis.
Despite technical and methodical advances in flow cytometry, its use in clinical routine is still limited.
Advantages and disadvantages of promising new parameters in diagnosis of sepsis performed by flow cytometry, particularly CD64, HLA-DR, and apoptosis, are reviewed here.
The necessity of tests to be used as an “ideal” parameter is presented.
American Psychological Association (APA)
Umlauf, Volker N.& Dreschers, Stephan& Orlikowsky, Thorsten W.. 2013. Flow Cytometry in the Detection of Neonatal Sepsis. International Journal of Pediatrics،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-496864
Modern Language Association (MLA)
Umlauf, Volker N.…[et al.]. Flow Cytometry in the Detection of Neonatal Sepsis. International Journal of Pediatrics No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-496864
American Medical Association (AMA)
Umlauf, Volker N.& Dreschers, Stephan& Orlikowsky, Thorsten W.. Flow Cytometry in the Detection of Neonatal Sepsis. International Journal of Pediatrics. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-496864
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496864