Downregulation of CD4+LAP+ and CD4+CD25+ Regulatory T Cells in Acute Coronary Syndromes
Joint Authors
Lu, Zheng-de
Wang, Xiao-yan
Huang, Ying
Shi, Ying
Lu, Shan-he
Lin, Ying-zhong
Ji, Qing-wei
Liu, Ling
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Regulatory T (Treg) cells play a protective role in atherosclerosis prone models and are related to the onset of acute coronary syndromes (ACS, including non-ST-elevation ACS (NSTEACS) and ST-elevation acute myocardial infarction (STEAMI)).
CD4+LAP+ Treg cells are a novel subset of Tregs that have been found to ameliorate atherosclerosis in ApoE-/- mice, and these cells also exist in humans.
The present study was designed to investigate whether CD4+LAP+ Treg cells are involved in the onset of ACS.
Methods.
The frequencies of CD4+LAP+ and CD4+CD25+ Treg cells were detected using flow cytometric analysis, and the plasma IL-10 and TGF-β1 levels were measured using an ELISA in 29 stable angina (SA) patients, 30 NSTEACS patients, 27 STEAMI patients, and a control group (30 cases).
Results.
The results revealed a significant decrease in the frequencies of CD4+LAP+ and CD4+CD25+ Treg cells and in the levels of IL-10 and TGF-β1 in patients with ACS compared with those in the SA and control groups.
Conclusions.
The decrease in the frequencies of CD4+LAP+ and CD4+CD25+ Treg cells may play a role in the onset of ACS.
American Psychological Association (APA)
Lin, Ying-zhong& Lu, Shan-he& Lu, Zheng-de& Huang, Ying& Shi, Ying& Liu, Ling…[et al.]. 2013. Downregulation of CD4+LAP+ and CD4+CD25+ Regulatory T Cells in Acute Coronary Syndromes. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-496946
Modern Language Association (MLA)
Lin, Ying-zhong…[et al.]. Downregulation of CD4+LAP+ and CD4+CD25+ Regulatory T Cells in Acute Coronary Syndromes. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-496946
American Medical Association (AMA)
Lin, Ying-zhong& Lu, Shan-he& Lu, Zheng-de& Huang, Ying& Shi, Ying& Liu, Ling…[et al.]. Downregulation of CD4+LAP+ and CD4+CD25+ Regulatory T Cells in Acute Coronary Syndromes. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-496946
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496946
