Inflammation and Microvasculopathy in Renal Ischemia Reperfusion Injury
Joint Authors
Patschan, Daniel
Müller, Gerhard Anton
Patschan, Susann
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Acute renal failure (ARF) severely worsens prognosis of hospitalized patients.
The most frequent cause of intrarenal ARF is transient or prolonged renal hypoperfusion (ischemia).
Ischemia primarily affects the function and structure of tubular epithelial cells, which, in severe cases, is characterized by epithelial cell necrosis.
Nevertheless, ischemia does not exclusively lead to alterations of epithelial cells but also causes interstitial inflammation and interstitial microvasculopathy.
Both inflammation and microvasculopathy are particularly important in terms of postischemic kidney repair.
Postischemic microvasculopathy is characterized by endothelial cell swelling with subsequent microvascular occlusion.
Thus, reperfusion is inhibited (no-reflow phenomenon).
Such endothelial cell dysfunction offers new therapeutic perspectives in ischemic ARF.
Newer observations point towards the role of the so-called endothelial progenitor cells (EPCs) in the treatment of ARF.
Systemic administration of EPCs to mice with bilateral renal ischemia mitigates postischemic endothelial cell dysfunction and protects animals from acute renal failure.
American Psychological Association (APA)
Patschan, Daniel& Patschan, Susann& Müller, Gerhard Anton. 2012. Inflammation and Microvasculopathy in Renal Ischemia Reperfusion Injury. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-496951
Modern Language Association (MLA)
Patschan, Daniel…[et al.]. Inflammation and Microvasculopathy in Renal Ischemia Reperfusion Injury. Journal of Transplantation No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-496951
American Medical Association (AMA)
Patschan, Daniel& Patschan, Susann& Müller, Gerhard Anton. Inflammation and Microvasculopathy in Renal Ischemia Reperfusion Injury. Journal of Transplantation. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-496951
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496951