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Development of Film Dosage Form Containing Allopurinol for Prevention and Treatment of Oral Mucositis
Joint Authors
Murata, Yoshifumi
Kamaguchi, Ryosei
Nishida, Norihisa
Kofuji, Kyoko
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Film dosage forms (FDs) containing allopurinol (AP) were prepared using a casting method with water-soluble polysaccharides, such as sodium alginate (ALG), and the release profile of AP from FDs was investigated in limited dissolution medium.
Some ALGs were able to form FDs incorporating AP, and the thickness was about 50 μm.
All FDs were easy to handle, though the rheological properties varied with ALG species.
AP was homogenously present throughout the FDs and was released with disintegration in 10 mL of physiological saline.
These results confirmed that FDs are useful for preventing or treating localized problems in the oral cavity, such as mucositis.
FDs are also useful for administering drugs to cancer patients receiving chemotherapy and/or radiotherapy.
American Psychological Association (APA)
Murata, Yoshifumi& Kofuji, Kyoko& Nishida, Norihisa& Kamaguchi, Ryosei. 2012. Development of Film Dosage Form Containing Allopurinol for Prevention and Treatment of Oral Mucositis. ISRN Pharmaceutics،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-496987
Modern Language Association (MLA)
Murata, Yoshifumi…[et al.]. Development of Film Dosage Form Containing Allopurinol for Prevention and Treatment of Oral Mucositis. ISRN Pharmaceutics No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-496987
American Medical Association (AMA)
Murata, Yoshifumi& Kofuji, Kyoko& Nishida, Norihisa& Kamaguchi, Ryosei. Development of Film Dosage Form Containing Allopurinol for Prevention and Treatment of Oral Mucositis. ISRN Pharmaceutics. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-496987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-496987