Induction of Specific CD8+ T Cells against Intracellular Bacteria by CD8+ T-Cell-Oriented Immunization Approaches

Joint Authors

Nagata, Toshi
Koide, Yukio

Source

Journal of Biomedicine and Biotechnology

Issue

Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2010-05-24

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Medicine

Abstract EN

For protection against intracellular bacteria such as Mycobacterium tuberculosis and Listeria monocytogenes, the cellular arm of adaptive immunity is necessary.

A variety of immunization methods have been evaluated and are reported to induce specific CD8+ T cells against intracellular bacterial infection.

Modified BCG vaccines have been examined to enhance CD8+ T-cell responses.

Naked DNA vaccination is a promising strategy to induce CD8+ T cells.

In addition to this strategy, live attenuated intracellular bacteria such as Shigella, Salmonella, and Listeria have been utilized as carriers of DNA vaccines in animal models.

Vaccination with dendritic cells pulsed with antigenic peptides or the cells introduced antigen genes by virus vectors such as retroviruses is also a powerful strategy.

Furthermore, vaccination with recombinant lentivirus has been attempted to induce specific CD8+ T cells.

Combinations of these strategies (prime-boost immunization) have been studied for the efficient induction of intracellular bacteria-specific CD8+ T cells.

American Psychological Association (APA)

Nagata, Toshi& Koide, Yukio. 2010. Induction of Specific CD8+ T Cells against Intracellular Bacteria by CD8+ T-Cell-Oriented Immunization Approaches. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-496993

Modern Language Association (MLA)

Nagata, Toshi& Koide, Yukio. Induction of Specific CD8+ T Cells against Intracellular Bacteria by CD8+ T-Cell-Oriented Immunization Approaches. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-496993

American Medical Association (AMA)

Nagata, Toshi& Koide, Yukio. Induction of Specific CD8+ T Cells against Intracellular Bacteria by CD8+ T-Cell-Oriented Immunization Approaches. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-496993

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-496993