![](/images/graphics-bg.png)
Alterations in Phosphorylated CREB Expression in Different Brain Regions following Short- and Long-Term Morphine Exposure : Relationship to Food Intake
Joint Authors
Lutfy, Kabirullah
Ren, Xiuhai
Mangubat, Michael
Liu, Yanjun
Ferrini, Monica G.
Friedman, Theodore C.
Lee, Martin L.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Activation of the cyclic adenosine monophosphate (cAMP)/phosphorylated CREB (P-CREB) system in different brain regions has been implicated in mediating opioid tolerance and dependence, while alteration of this system in the lateral hypothalamus (LH) has been suggested to have a role in food intake and body weight.
Methods.
Given that opioids regulate food intake, we measured P-CREB in different brain regions in mice exposed to morphine treatments designed to induce different degrees of tolerance and dependence.
Results.
We found that a single morphine injection or daily morphine injections for 8 days did not influence P-CREB levels, while the escalating dose of morphine regimen raised P-CREB levels only in the ventral tegmental area (VTA).
Chronic morphine pellet implantation for 7 days raised P-CREB levels in the LH, VTA, and dorsomedial nucleus of the hypothalamus (DM) but not in the nucleus accumbens and amygdala.
Increased P-CREB levels in LH, VTA, and DM following 7-day treatment with morphine pellets and increased P-CREB levels in the VTA following escalating doses of morphine were associated with decreased food intake and body weight.
Conclusion.
The morphine regulation of P-CREB may explain some of the physiological sequelae of opioid exposure including altered food intake and body weight.
American Psychological Association (APA)
Ren, Xiuhai& Lutfy, Kabirullah& Mangubat, Michael& Ferrini, Monica G.& Lee, Martin L.& Liu, Yanjun…[et al.]. 2013. Alterations in Phosphorylated CREB Expression in Different Brain Regions following Short- and Long-Term Morphine Exposure : Relationship to Food Intake. Journal of Obesity،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-497011
Modern Language Association (MLA)
Ren, Xiuhai…[et al.]. Alterations in Phosphorylated CREB Expression in Different Brain Regions following Short- and Long-Term Morphine Exposure : Relationship to Food Intake. Journal of Obesity No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-497011
American Medical Association (AMA)
Ren, Xiuhai& Lutfy, Kabirullah& Mangubat, Michael& Ferrini, Monica G.& Lee, Martin L.& Liu, Yanjun…[et al.]. Alterations in Phosphorylated CREB Expression in Different Brain Regions following Short- and Long-Term Morphine Exposure : Relationship to Food Intake. Journal of Obesity. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-497011
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497011