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Persistent Penumbra in a Rabbit Stroke Model : Incidence and Histologic Characteristics
Joint Authors
Hennings, Leah J.
Brown, Aliza
Culp, William C.
Roberson, Paula K.
Borrelli, Michael
Lowery, John
Flores, Rene
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Duration and extent of penumbra determine the window and brain volume in which interventions may save injured tissue after stroke.
Understanding the penumbra in animals is necessary in order to design models that translate to effective clinical therapies.
New Zealand white rabbits were embolized with aged autologous clot (n=23) or insoluble microspheres (n=21).
To examine effects of treatment on penumbra, sphere-stroked animals were treated with 3 μm microbubbles plus ultrasound (n=19).
Rabbits were euthanized at 4 or 24 hr.
Infarct volume was measured following triphenyltetrazolium chloride (TTC) staining of brain sections.
Penumbra was visualized using immunostaining of pimonidazole injected fifteen minutes prior to euthanasia.
Potentially reversible penumbra was present in 14.3% stroked rabbits at 4 hours and 15.7% at 24 hours after embolic stroke and represented up to 35% of total lost tissue.
Intervention at up to 24 hours may benefit a significant patient population.
American Psychological Association (APA)
Hennings, Leah J.& Flores, Rene& Roberson, Paula K.& Brown, Aliza& Lowery, John& Borrelli, Michael…[et al.]. 2011. Persistent Penumbra in a Rabbit Stroke Model : Incidence and Histologic Characteristics. Stroke Research and Treatment،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-497018
Modern Language Association (MLA)
Hennings, Leah J.…[et al.]. Persistent Penumbra in a Rabbit Stroke Model : Incidence and Histologic Characteristics. Stroke Research and Treatment No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-497018
American Medical Association (AMA)
Hennings, Leah J.& Flores, Rene& Roberson, Paula K.& Brown, Aliza& Lowery, John& Borrelli, Michael…[et al.]. Persistent Penumbra in a Rabbit Stroke Model : Incidence and Histologic Characteristics. Stroke Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-497018
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497018