Lead Discovery for Alzheimer’s Disease Related Target Protein RbAp48 from Traditional Chinese Medicine
Joint Authors
Lee, Cheng-Chun
Chen, Calvin Yu-Chian
Huang, Hung-Jin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-02
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Deficiency or loss of function of Retinoblastoma-associated proteins (RbAp48) is related with Alzheimer’s disease (AD), and AD disease is associated with age-related memory loss.
During normal function, RbAp48 forms a complex with the peptide FOG-1 (friend of GATA-1) and has a role in gene transcription, but an unstable complex may affect the function of RbAp48.
This study utilizes the world’s largest traditional Chinese medicine (TCM) database and virtual screening to provide potential compounds for RbAp48 binding.
A molecular dynamics (MD) simulation was employed to understand the variations after protein-ligand interaction.
FOG1 was found to exhibit low stability after RbAp48 binding; the peptide displayed significant movement from the initial docking position, a phenomenon which matched the docking results.
The protein structure of the other TCM candidates was not variable during MD simulation and had a greater stable affinity for RbAp48 binding than FOG1.
Our results reveal that the protein structure does not affect ligand binding, and the top three TCM candidates Bittersweet alkaloid II, Eicosandioic acid, and Perivine might resolve the instability of the RbAp48-FOG1 complex and thus be used in AD therapy.
American Psychological Association (APA)
Huang, Hung-Jin& Lee, Cheng-Chun& Chen, Calvin Yu-Chian. 2014. Lead Discovery for Alzheimer’s Disease Related Target Protein RbAp48 from Traditional Chinese Medicine. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-497030
Modern Language Association (MLA)
Huang, Hung-Jin…[et al.]. Lead Discovery for Alzheimer’s Disease Related Target Protein RbAp48 from Traditional Chinese Medicine. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-497030
American Medical Association (AMA)
Huang, Hung-Jin& Lee, Cheng-Chun& Chen, Calvin Yu-Chian. Lead Discovery for Alzheimer’s Disease Related Target Protein RbAp48 from Traditional Chinese Medicine. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-497030
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497030