Derivation of Two New Human Embryonic Stem Cell Lines from Nonviable Human Embryos
Joint Authors
Gavrilov, Svetlana
Douglas, Nataki C.
Landry, Donald W.
Khalid, Imran
Marolt, Darja
Vunjak-Novakovic, Gordana
Sauer, Mark V.
Prosser, Robert W.
Papaioannou, Virginia E.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
We report the derivation and characterization of two new human embryonic stem cells (hESC) lines (CU1 and CU2) from embryos with an irreversible loss of integrated organismic function.
In addition, we analyzed retrospective data of morphological progression from embryonic day (ED) 5 to ED6 for 2480 embryos not suitable for clinical use to assess grading criteria indicative of loss of viability on ED5.
Our analysis indicated that a large proportion of in vitro fertilization (IVF) embryos not suitable for clinical use could be used for hESC derivation.
Based on these combined findings, we propose that criteria commonly used in IVF clinics to determine optimal embryos for uterine transfer can be employed to predict the potential for hESC derivation from poor quality embryos without the destruction of vital human embryos.
American Psychological Association (APA)
Gavrilov, Svetlana& Marolt, Darja& Douglas, Nataki C.& Prosser, Robert W.& Khalid, Imran& Sauer, Mark V.…[et al.]. 2011. Derivation of Two New Human Embryonic Stem Cell Lines from Nonviable Human Embryos. Stem Cells International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-497062
Modern Language Association (MLA)
Gavrilov, Svetlana…[et al.]. Derivation of Two New Human Embryonic Stem Cell Lines from Nonviable Human Embryos. Stem Cells International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-497062
American Medical Association (AMA)
Gavrilov, Svetlana& Marolt, Darja& Douglas, Nataki C.& Prosser, Robert W.& Khalid, Imran& Sauer, Mark V.…[et al.]. Derivation of Two New Human Embryonic Stem Cell Lines from Nonviable Human Embryos. Stem Cells International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-497062
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497062