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The Roles of Interleukin-6 in the Pathogenesis of Rheumatoid Arthritis
Joint Authors
Hashizume, Misato
Mihara, Masahiko
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Several clinical studies have demonstrated that the humanized anti-interleukin-6 (IL-6) receptor antibody tocilizumab (TCZ) improves clinical symptoms and prevents progression of joint destruction in rheumatoid arthritis (RA).
However, the precise mechanism by which IL-6 blockade leads to the improvement of RA is not well understood.
IL-6 promotes synovitis by inducing neovascularization, infiltration of inflammatory cells, and synovial hyperplasia.
IL-6 causes bone resorption by inducing osteoclast formation via the induction of RANKL in synovial cells, and cartilage degeneration by producing matrix metalloproteinases (MMPs) in synovial cells and chondrocytes.
Moreover, IL-6 is involved in autoimmunity by altering the balance between Th17 cells and Treg.
IL-6 also acts on changing lipid concentrations in blood and on inducing the production of hepcidin which causes iron-deficient anemia.
In conclusion, IL-6 is a major player in the pathogenesis of RA, and current evidence indicates that the blockade of IL-6 is a beneficial therapy for RA patients.
American Psychological Association (APA)
Hashizume, Misato& Mihara, Masahiko. 2011. The Roles of Interleukin-6 in the Pathogenesis of Rheumatoid Arthritis. Arthritis،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-497081
Modern Language Association (MLA)
Hashizume, Misato& Mihara, Masahiko. The Roles of Interleukin-6 in the Pathogenesis of Rheumatoid Arthritis. Arthritis No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-497081
American Medical Association (AMA)
Hashizume, Misato& Mihara, Masahiko. The Roles of Interleukin-6 in the Pathogenesis of Rheumatoid Arthritis. Arthritis. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-497081
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497081