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Design, Synthesis, and In Vitro Antioxidant Activity of 1,3,5-Trisubstituted-2-pyrazolines Derivatives
Joint Authors
Soni, Neeraj
Verma, Amita
Jagadish, P. C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Mannich base of pyrazolines 3(a–e) under both conventional and microwave irradiation was synthesized.
All the synthesised compounds were purified by recrystallisation, characterized on the basis of UV, IR, and NMR spectroscopy, and further supported by mass spectroscopy.
The result obtained confirms superiority of microwave irradiation method over classical heating one.
The molecular properties and Lipinski rule of five for compounds 3(a–e) were determined by Molinspiration.
The synthesized compounds were subsequently evaluated for the antioxidant activity.
All the compounds were found in compliance with Lipinski “Rule of Five”, and compound 3e having p-hydroxyl substitution showed best antioxidant activity as compared to ascorbic acid and rutin.
American Psychological Association (APA)
Jagadish, P. C.& Soni, Neeraj& Verma, Amita. 2013. Design, Synthesis, and In Vitro Antioxidant Activity of 1,3,5-Trisubstituted-2-pyrazolines Derivatives. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-497104
Modern Language Association (MLA)
Jagadish, P. C.…[et al.]. Design, Synthesis, and In Vitro Antioxidant Activity of 1,3,5-Trisubstituted-2-pyrazolines Derivatives. Journal of Chemistry No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-497104
American Medical Association (AMA)
Jagadish, P. C.& Soni, Neeraj& Verma, Amita. Design, Synthesis, and In Vitro Antioxidant Activity of 1,3,5-Trisubstituted-2-pyrazolines Derivatives. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-497104
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497104