Mitochondrial FusionFission, Transport and Autophagy in Parkinson's Disease : When Mitochondria Get Nasty
Joint Authors
Cardoso, Sandra M.
Arduíno, Daniela M.
Esteves, A. Raquel
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Understanding the molecular basis of Parkinson's disease (PD) has proven to be a major challenge in the field of neurodegenerative diseases.
Although several hypotheses have been proposed to explain the molecular mechanisms underlying the pathogenesis of PD, a growing body of evidence has highlighted the role of mitochondrial dysfunction and the disruption of the mechanisms of mitochondrial dynamics in PD and other parkinsonian disorders.
In this paper, we comment on the recent advances in how changes in the mitochondrial function and mitochondrial dynamics (fusion/fission, transport, and clearance) contribute to neurodegeneration, specifically focusing on PD.
We also evaluate the current controversies in those issues and discuss the role of fusion/fission dynamics in the mitochondrial lifecycle and maintenance.
We propose that cellular demise and neurodegeneration in PD are due to the interplay between mitochondrial dysfunction, mitochondrial trafficking disruption, and impaired autophagic clearance.
American Psychological Association (APA)
Arduíno, Daniela M.& Esteves, A. Raquel& Cardoso, Sandra M.. 2011. Mitochondrial FusionFission, Transport and Autophagy in Parkinson's Disease : When Mitochondria Get Nasty. Case Reports in Medicine،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-497140
Modern Language Association (MLA)
Arduíno, Daniela M.…[et al.]. Mitochondrial FusionFission, Transport and Autophagy in Parkinson's Disease : When Mitochondria Get Nasty. Case Reports in Medicine No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-497140
American Medical Association (AMA)
Arduíno, Daniela M.& Esteves, A. Raquel& Cardoso, Sandra M.. Mitochondrial FusionFission, Transport and Autophagy in Parkinson's Disease : When Mitochondria Get Nasty. Case Reports in Medicine. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-497140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497140