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The Role of Ets Factors in Tumor Angiogenesis
Author
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Angiogenesis is a critical component of tumor growth.
A number of growth factors, including VEGF, FGF, and HGF, have been implicated as angiogenic growth factors that promote tumor angiogenesis in different types of cancer.
Ets-1 is the prototypic member of the Ets transcription factor family.
Ets-1 is known to be a downstream mediator of angiogenic growth factors.
Expression of Ets-1 in a variety of different tumors is associated with increased angiogenesis.
A role for other selected members of the Ets transcription factor family has also been shown to be important for the development of tumor angiogenesis.
Because Ets factors also express a number of other important genes involved in cell growth, they contribute not only to tumor growth, but to disease progression.
Targeting Ets factors in mouse tumor models through the use of dominant-negative Ets proteins or membrane permeable peptides directed at competitively inhibiting the DNA binding domain has now demonstrated the therapeutic potential of inhibiting selected Ets transcription factors to limit tumor growth and disease progression.
American Psychological Association (APA)
Oettgen, Peter. 2010. The Role of Ets Factors in Tumor Angiogenesis. Journal of Oncology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-497156
Modern Language Association (MLA)
Oettgen, Peter. The Role of Ets Factors in Tumor Angiogenesis. Journal of Oncology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-497156
American Medical Association (AMA)
Oettgen, Peter. The Role of Ets Factors in Tumor Angiogenesis. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-497156
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497156