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Galangin Abrogates Ovalbumin-Induced Airway Inflammation via Negative Regulation of NF-κB
Joint Authors
Shen, Yi
Du, Qiang
Qian, Yan
Li, Xiao
Chen, Fei-Fei
Zha, Wang-Jian
Huang, Mao
Wu, Zhen-Zhen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-25
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Persistent activation of nuclear factor κB (NF-κB) has been associated with the development of asthma.
Galangin, the active pharmacological ingredient from Alpinia galanga, is reported to have a variety of anti-inflammatory properties in vitro via negative regulation of NF-κB.
This study aimed to investigate whether galangin can abrogate ovalbumin- (OVA-) induced airway inflammation by negative regulation of NF-κB.
BALB/c mice sensitized and challenged with OVA developed airway hyperresponsiveness (AHR) and inflammation.
Galangin dose dependently inhibited OVA-induced increases in total cell counts, eosinophil counts, and interleukin-(IL-) 4, IL-5, and IL-13 levels in bronchoalveolar lavage fluid, and reduced serum level of OVA-specific IgE.
Galangin also attenuated AHR, reduced eosinophil infiltration and goblet cell hyperplasia, and reduced expression of inducible nitric oxide synthase and vascular cell adhesion protein-1 (VCAM-1) levels in lung tissue.
Additionally, galangin blocked inhibitor of κB degradation, phosphorylation of the p65 subunit of NF-κB, and p65 nuclear translocation from lung tissues of OVA-sensitized mice.
Similarly, in normal human airway smooth muscle cells, galangin blocked tumor necrosis factor-α induced p65 nuclear translocation and expression of monocyte chemoattractant protein-1, eotaxin, CXCL10, and VCAM-1.
These results suggest that galangin can attenuate ovalbumin-induced airway inflammation by inhibiting the NF-κB pathway.
American Psychological Association (APA)
Zha, Wang-Jian& Qian, Yan& Shen, Yi& Du, Qiang& Chen, Fei-Fei& Wu, Zhen-Zhen…[et al.]. 2013. Galangin Abrogates Ovalbumin-Induced Airway Inflammation via Negative Regulation of NF-κB. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-497173
Modern Language Association (MLA)
Zha, Wang-Jian…[et al.]. Galangin Abrogates Ovalbumin-Induced Airway Inflammation via Negative Regulation of NF-κB. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-497173
American Medical Association (AMA)
Zha, Wang-Jian& Qian, Yan& Shen, Yi& Du, Qiang& Chen, Fei-Fei& Wu, Zhen-Zhen…[et al.]. Galangin Abrogates Ovalbumin-Induced Airway Inflammation via Negative Regulation of NF-κB. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-497173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497173