PLGA Nanoparticles for Ultrasound-Mediated Gene Delivery to Solid Tumors
Joint Authors
Figueiredo, Marxa
Esenaliev, Rinat
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
This paper focuses on novel approaches in the field of nanotechnology-based carriers utilizing ultrasound stimuli as a means to spatially target gene delivery in vivo, using nanoparticles made with either poly(lactic-co-glycolic acid) (PLGA) or other polymers.
We specifically discuss the potential for gene delivery by particles that are echogenic (amenable to destruction by ultrasound) composed either of polymers (PLGA, polystyrene) or other contrast agent materials (Optison, SonoVue microbubbles).
The use of ultrasound is an efficient tool to further enhance gene delivery by PLGA or other echogenic particles in vivo.
Echogenic PLGA nanoparticles are an attractive strategy for ultrasound-mediated gene delivery since this polymer is currently approved by the US Food and Drug Administration for drug delivery and diagnostics in cancer, cardiovascular disease, and also other applications such as vaccines and tissue engineering.
This paper will review recent successes and the potential of applying PLGA nanoparticles for gene delivery, which include (a) echogenic PLGA used with ultrasound to enhance local gene delivery in tumors or muscle and (b) PLGA nanoparticles currently under development, which could benefit in the future from ultrasound-enhanced tumor targeted gene delivery.
American Psychological Association (APA)
Figueiredo, Marxa& Esenaliev, Rinat. 2012. PLGA Nanoparticles for Ultrasound-Mediated Gene Delivery to Solid Tumors. Journal of Drug Delivery،Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-497179
Modern Language Association (MLA)
Figueiredo, Marxa& Esenaliev, Rinat. PLGA Nanoparticles for Ultrasound-Mediated Gene Delivery to Solid Tumors. Journal of Drug Delivery No. 2012 (2012), pp.1-20.
https://search.emarefa.net/detail/BIM-497179
American Medical Association (AMA)
Figueiredo, Marxa& Esenaliev, Rinat. PLGA Nanoparticles for Ultrasound-Mediated Gene Delivery to Solid Tumors. Journal of Drug Delivery. 2012. Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-497179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497179