Ginsenoside Rb1 Preconditioning Enhances eNOS Expression and Attenuates Myocardial IschemiaReperfusion Injury in Diabetic Rats
Joint Authors
Wu, Yang
Zhang, Li
Zhao, Bo
Xia, Zhong-yuan
Xia, Rui
Hou, Jia-Bao
Xu, Jin-Jin
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Diabetes mellitus is associated with decreased NO bioavailability in the myocardium.
Ginsenoside Rb1 has been shown to confer cardioprotection against ischemia reperfusion injury.
The aim of this study was to investigate whether Ginsenoside Rb1 exerts cardioprotective effects during myocardial ischemia-reperfusion in diabetic rats and whether this effect is related to increase the production of NO via enhancing eNOS expression in the myocardium.
The myocardial I/R injury were induced by occluding the left anterior descending artery for 30 min followed by 120 min reperfusion.
An eNOS inhibitor L-NAME or Rb1 were respectively administered 25 min or 10 min before inducing ischemia.
Ginsenoside Rb1 preconditioning reduced myocardial infarct size when compared with I/R group.
Ginsenoside Rb1 induced myocardial protection was accompanied with increased eNOS expression and NO concentration and reduced plasma CK and LDH (P<0.05).
Moreover, the myocardial oxidative stress and tissue histological damage was attenuated by Ginsenoside Rb1 (P<0.05).
L-NAME abolished the protective effects of Ginsenoside Rb1.
It is concluded that Ginsenoside Rb1 protects against myocardium ischemia/reperfusion injury in diabetic rat by enhancing the expression of eNOS and increasing the content of NO as well as inhibiting oxidative stress.
American Psychological Association (APA)
Xia, Rui& Zhao, Bo& Wu, Yang& Hou, Jia-Bao& Zhang, Li& Xu, Jin-Jin…[et al.]. 2011. Ginsenoside Rb1 Preconditioning Enhances eNOS Expression and Attenuates Myocardial IschemiaReperfusion Injury in Diabetic Rats. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-497188
Modern Language Association (MLA)
Xia, Rui…[et al.]. Ginsenoside Rb1 Preconditioning Enhances eNOS Expression and Attenuates Myocardial IschemiaReperfusion Injury in Diabetic Rats. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-497188
American Medical Association (AMA)
Xia, Rui& Zhao, Bo& Wu, Yang& Hou, Jia-Bao& Zhang, Li& Xu, Jin-Jin…[et al.]. Ginsenoside Rb1 Preconditioning Enhances eNOS Expression and Attenuates Myocardial IschemiaReperfusion Injury in Diabetic Rats. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-497188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497188