Attenuation of Acute Lung Inflammation and Injury by Whole Body Cooling in a Rat Heatstroke Model
Joint Authors
Cheng, Ruei-Tang
Yang, Hsi-Hsing
Lin, Mao- Tsun
Chang, Ching-Ping
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Whole body cooling is the current therapy of choice for heatstroke because the therapeutic agents are not available.
In this study, we assessed the effects of whole body cooling on several indices of acute lung inflammation and injury which might occur during heatstroke.
Anesthetized rats were randomized into the following groups and given (a) no treatment or (b) whole body cooling immediately after onset of heatstroke.
As compared with the normothermic controls, the untreated heatstroke rats had higher levels of pleural exudates volume and polymorphonuclear cell numbers, lung myloperoxidase activity and inducible nitric oxide synthase expression, histologic lung injury score, and bronchoalveolar proinflammatory cytokines and glutamate, and PaCO2.
In contrast, the values of mean arterial pressure, heart rate, PaO2, pH, and blood HCO3− were all significantly lower during heatstroke.
The acute lung inflammation and injury and electrolyte imbalance that occurred during heatstroke were significantly reduced by whole body cooling.
In conclusion, we identified heat-induced acute lung inflammation and injury and electrolyte imbalance could be ameliorated by whole body cooling.
American Psychological Association (APA)
Yang, Hsi-Hsing& Chang, Ching-Ping& Cheng, Ruei-Tang& Lin, Mao- Tsun. 2009. Attenuation of Acute Lung Inflammation and Injury by Whole Body Cooling in a Rat Heatstroke Model. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-497200
Modern Language Association (MLA)
Yang, Hsi-Hsing…[et al.]. Attenuation of Acute Lung Inflammation and Injury by Whole Body Cooling in a Rat Heatstroke Model. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-497200
American Medical Association (AMA)
Yang, Hsi-Hsing& Chang, Ching-Ping& Cheng, Ruei-Tang& Lin, Mao- Tsun. Attenuation of Acute Lung Inflammation and Injury by Whole Body Cooling in a Rat Heatstroke Model. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-497200
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497200