A Nonpolar Blueberry Fraction Blunts NADPH Oxidase Activation in Neuronal Cells Exposed to Tumor Necrosis Factor-α

Joint Authors

Kuhn, Thomas B.
Dunlap, Kriya L.
McGill, Colin M.
Gustafson, Sally J.

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-03-13

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Natural & Life Sciences (Multidisciplinary)
Biology

Abstract EN

Inflammation and oxidative stress are key to the progressive neuronal degeneration common to chronic pathologies, traumatic injuries, and aging processes in the CNS.

The proinflammatory cytokine tumor necrosis factor-alpha (TNF-α) orchestrates cellular stress by stimulating the production and release of neurotoxic mediators including reactive oxygen species (ROS).

NADPH oxidases (NOX), ubiquitously expressed in all cells, have recently emerged as pivotal ROS sources in aging and disease.

We demonstrated the presence of potent NOX inhibitors in wild Alaska bog blueberries partitioning discretely into a nonpolar fraction with minimal antioxidant capacity and largely devoid of polyphenols.

Incubation of SH-SY5Y human neuroblastoma cells with nonpolar blueberry fractions obstructed the coalescing of lipid rafts into large domains disrupting NOX assembly therein and abolishing ROS production characteristic for TNF-α exposure.

These findings illuminate nutrition-derived lipid raft modulation as a novel therapeutic approach to blunt inflammatory and oxidative stress in the aging or diseased CNS.

American Psychological Association (APA)

Gustafson, Sally J.& Dunlap, Kriya L.& McGill, Colin M.& Kuhn, Thomas B.. 2012. A Nonpolar Blueberry Fraction Blunts NADPH Oxidase Activation in Neuronal Cells Exposed to Tumor Necrosis Factor-α. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-497202

Modern Language Association (MLA)

Gustafson, Sally J.…[et al.]. A Nonpolar Blueberry Fraction Blunts NADPH Oxidase Activation in Neuronal Cells Exposed to Tumor Necrosis Factor-α. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-497202

American Medical Association (AMA)

Gustafson, Sally J.& Dunlap, Kriya L.& McGill, Colin M.& Kuhn, Thomas B.. A Nonpolar Blueberry Fraction Blunts NADPH Oxidase Activation in Neuronal Cells Exposed to Tumor Necrosis Factor-α. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-497202

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-497202