Molecular Mechanisms for Age-Associated Mitochondrial Deficiency in Skeletal Muscle
Joint Authors
Wagatsuma, Akira
Sakuma, Kunihiro
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-04
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
The abundance, morphology, and functional properties of mitochondria decay in skeletal muscle during the process of ageing.
Although the precise mechanisms remain to be elucidated, these mechanisms include decreased mitochondrial DNA (mtDNA) repair and mitochondrial biogenesis.
Mitochondria possess their own protection system to repair mtDNA damage, which leads to defects of mtDNA-encoded gene expression and respiratory chain complex enzymes.
However, mtDNA mutations have shown to be accumulated with age in skeletal muscle.
When damaged mitochondria are eliminated by autophagy, mitochondrial biogenesis plays an important role in sustaining energy production and physiological homeostasis.
The capacity for mitochondrial biogenesis has shown to decrease with age in skeletal muscle, contributing to progressive mitochondrial deficiency.
Understanding how these endogenous systems adapt to altered physiological conditions during the process of ageing will provide a valuable insight into the underlying mechanisms that regulate cellular homeostasis.
Here we will summarize the current knowledge about the molecular mechanisms responsible for age-associated mitochondrial deficiency in skeletal muscle.
In particular, recent findings on the role of mtDNA repair and mitochondrial biogenesis in maintaining mitochondrial functionality in aged skeletal muscle will be highlighted.
American Psychological Association (APA)
Wagatsuma, Akira& Sakuma, Kunihiro. 2012. Molecular Mechanisms for Age-Associated Mitochondrial Deficiency in Skeletal Muscle. Journal of Aging Research،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-497232
Modern Language Association (MLA)
Wagatsuma, Akira& Sakuma, Kunihiro. Molecular Mechanisms for Age-Associated Mitochondrial Deficiency in Skeletal Muscle. Journal of Aging Research No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-497232
American Medical Association (AMA)
Wagatsuma, Akira& Sakuma, Kunihiro. Molecular Mechanisms for Age-Associated Mitochondrial Deficiency in Skeletal Muscle. Journal of Aging Research. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-497232
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497232