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High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period
Joint Authors
Fawwaz, Rashid A.
DeLaPaz, Robert L.
Cleveland, W. Louis
Challop, Roger S.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-18
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
This paper describes an individual who was diagnosed with obsessive-compulsive disorder (OCD) and body dysmorphic disorder (BDD) at age 17 when education was discontinued.
By age 19, he was housebound without social contacts except for parents.
Adequate trials of three selective serotonin reuptake inhibitors, two with atypical neuroleptics, were ineffective.
Major exacerbations following ear infections involving Group A β-hemolytic streptococcus at ages 19 and 20 led to intravenous immune globulin therapy, which was also ineffective.
At age 22, another severe exacerbation followed antibiotic treatment for H.
pylori.
This led to a hypothesis that postulates deficient signal transduction by the N-methyl-D-aspartate receptor (NMDAR).
Treatment with glycine, an NMDAR coagonist, over 5 years led to robust reduction of OCD/BDD signs and symptoms except for partial relapses during treatment cessation.
Education and social life were resumed and evidence suggests improved cognition.
Our findings motivate further study of glycine treatment of OCD and BDD.
American Psychological Association (APA)
Cleveland, W. Louis& DeLaPaz, Robert L.& Fawwaz, Rashid A.& Challop, Roger S.. 2010. High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period. Neural Plasticity،Vol. 2009, no. 2009, pp.1-25.
https://search.emarefa.net/detail/BIM-497239
Modern Language Association (MLA)
Cleveland, W. Louis…[et al.]. High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period. Neural Plasticity No. 2009 (2009), pp.1-25.
https://search.emarefa.net/detail/BIM-497239
American Medical Association (AMA)
Cleveland, W. Louis& DeLaPaz, Robert L.& Fawwaz, Rashid A.& Challop, Roger S.. High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period. Neural Plasticity. 2010. Vol. 2009, no. 2009, pp.1-25.
https://search.emarefa.net/detail/BIM-497239
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497239