Tuberculosis Immunity : Opportunities from Studies with Cattle
Joint Authors
Hope, Jayne C.
Sreevatsan, Srinand
Thacker, Tyler C.
Meade, Kieran G.
Estes, Don Mark
Coussens, Paul M.
Waters, W. Ray
Davis, William C.
Palmer, Mitchell V.
Source
Clinical and Developmental Immunology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Mycobacterium tuberculosis and M.
bovis share >99% genetic identity and induce similar host responses and disease profiles upon infection.
There is a rich history of codiscovery in the development of control measures applicable to both human and bovine tuberculosis (TB) including skin-testing procedures, M.
bovis BCG vaccination, and interferon-γ release assays.
The calf TB infection model offers several opportunities to further our understanding of TB immunopathogenesis.
Recent observations include correlation of central memory immune responses with TB vaccine efficacy, association of SIRPα+ cells in ESAT-6:CFP10-elicited multinucleate giant cell formation, early γδ T cell responses to TB, antimycobacterial activity of memory CD4+ T cells via granulysin production, association of specific antibody with antigen burden, and suppression of innate immune gene expression in infected animals.
Partnerships teaming researchers with veterinary and medical perspectives will continue to provide mutual benefit to TB research in man and animals.
American Psychological Association (APA)
Waters, W. Ray& Palmer, Mitchell V.& Thacker, Tyler C.& Davis, William C.& Sreevatsan, Srinand& Coussens, Paul M.…[et al.]. 2010. Tuberculosis Immunity : Opportunities from Studies with Cattle. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-497253
Modern Language Association (MLA)
Waters, W. Ray…[et al.]. Tuberculosis Immunity : Opportunities from Studies with Cattle. Clinical and Developmental Immunology No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-497253
American Medical Association (AMA)
Waters, W. Ray& Palmer, Mitchell V.& Thacker, Tyler C.& Davis, William C.& Sreevatsan, Srinand& Coussens, Paul M.…[et al.]. Tuberculosis Immunity : Opportunities from Studies with Cattle. Clinical and Developmental Immunology. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-497253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497253