Short-Term Calorie Restriction in Early Life Attenuates the Development of Proteinuria but Not Glucose Intolerance in Type 2 Diabetic OLETF Rats
Joint Authors
Nishiyama, Akira
Hitomi, Hirofumi
Masaki, Tsutomu
Diah, Suwarni
Nakano, Daisuke
Mori, Hirohito
Kitada, Kento
Kobori, Hiroyuki
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Childhood obesity is becoming more prevalent; however, the influence of obesity or dieting during childhood on outcomes in adulthood is poorly understood.
The aim of this study was to examine the effects of short-term calorie restriction (CR) and high-calorie feeding with high-fat or high-sucrose diets during early life on the development of glucose tolerance and diabetic nephropathy in later life of Otsuka Long-Evans Tokushima fatty (OLETF) rats.
Neither high-calorie intake nor CR at 7–13 weeks of age affected glucose tolerance of 27-week-old OLETF rats.
On the other hand, proteinuria was lower at 27 weeks of age in CR rats than in the other rats.
These results suggest that short-term CR at a young age protects against the development of renal injury in later life.
In contrast, short-term high-calorie intake or CR at a young age does not appear to affect glucose metabolism in later life.
American Psychological Association (APA)
Nakano, Daisuke& Diah, Suwarni& Kitada, Kento& Hitomi, Hirofumi& Mori, Hirohito& Masaki, Tsutomu…[et al.]. 2011. Short-Term Calorie Restriction in Early Life Attenuates the Development of Proteinuria but Not Glucose Intolerance in Type 2 Diabetic OLETF Rats. ISRN Endocrinology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-497266
Modern Language Association (MLA)
Nakano, Daisuke…[et al.]. Short-Term Calorie Restriction in Early Life Attenuates the Development of Proteinuria but Not Glucose Intolerance in Type 2 Diabetic OLETF Rats. ISRN Endocrinology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-497266
American Medical Association (AMA)
Nakano, Daisuke& Diah, Suwarni& Kitada, Kento& Hitomi, Hirofumi& Mori, Hirohito& Masaki, Tsutomu…[et al.]. Short-Term Calorie Restriction in Early Life Attenuates the Development of Proteinuria but Not Glucose Intolerance in Type 2 Diabetic OLETF Rats. ISRN Endocrinology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-497266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497266
