Clinical and Electrocardiographic Evaluation of Sickle-Cell Anaemia Patients with Pulmonary Hypertension
Joint Authors
Oguanobi, N. I.
Onwubere, Basden J. C.
Ejim, E. C.
Anisiuba, B. C.
Ibegbulam, O. G.
Ike, S. O.
Agwu, O.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Pulmonary hypertension is an emerging complication of sickle cell anaemia with associated increased risk of mortality.
In order to evaluate the clinical and electrocardiographic findings in adult sickle-cell patients with pulmonary hypertension, a cross sectional study was conducted on sixty two sickle cell anaemia patients and sixty two age and sex matched normal controls.
Elevated pulmonary artery pressures (PAP), defined by PAP ≥ 30 mm Hg on echocardiography, was demonstrated in 41.9% of patients with sickle cell anaemia and in 3.2% of the controls; χ2=26.571, P<0.001.
Right ventricular hypertrophy, increased P-wave duration, QTc interval, and QTc dispersion were significantly associated with pulmonary hypertension.
Significant correlation was found between mean PAP and (1) Frequency of crisis (Spearman correlation = 0.320; P=0.011), (2) body mass index (Pearson’s correlation = −0.297; P=0.019), and (3) QTc interval (Pearson’s correlation 0.261; P=0.040).
Pulmonary hypertension in adult sickle anaemia patients is associated with electrocardiographic evidence of right ventricular hypertrophy, and correlates significantly with frequency of vaso-occlusive crisis, and QTc interval.
The observations by this study tend to suggest that these parameters could be useful for early detection and prevention of pulmonary hypertension in patients with sickle cell anaemia.
American Psychological Association (APA)
Oguanobi, N. I.& Ejim, E. C.& Anisiuba, B. C.& Onwubere, Basden J. C.& Ike, S. O.& Ibegbulam, O. G.…[et al.]. 2012. Clinical and Electrocardiographic Evaluation of Sickle-Cell Anaemia Patients with Pulmonary Hypertension. ISRN Hematology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-497273
Modern Language Association (MLA)
Oguanobi, N. I.…[et al.]. Clinical and Electrocardiographic Evaluation of Sickle-Cell Anaemia Patients with Pulmonary Hypertension. ISRN Hematology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-497273
American Medical Association (AMA)
Oguanobi, N. I.& Ejim, E. C.& Anisiuba, B. C.& Onwubere, Basden J. C.& Ike, S. O.& Ibegbulam, O. G.…[et al.]. Clinical and Electrocardiographic Evaluation of Sickle-Cell Anaemia Patients with Pulmonary Hypertension. ISRN Hematology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-497273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497273