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The Use of Interferon Gamma Release Assays in the Diagnosis of Active Tuberculosis
Joint Authors
Rüssmann, Holger
Mauch, Harald
Schönfeld, Nicolas
Bauer, Torsten T.
Bergmann, Thorsten
Wagner, Sonja
Vesenbeckh, Silvan M.
Source
Tuberculosis Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-22
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Interferon gamma release assays (IGRAs) are in vitro immunologic diagnostic tests used to identify Mycobacterium tuberculosis infection.
They cannot differentiate between latent and active infections.
The cutoff suggested by the manufacturer is 0.35 IU/mL for latent tuberculosis.
As IGRA tests were recently approved for the differential diagnosis of active tuberculosis, we assessed the diagnostic accuracy of the latest generation IGRA for detection of active tuberculosis in a low-incidence area in Germany.
Our consecutive case series includes 61 HIV negative, Mycobacterium tuberculosis culture positive patients, as well as 234 control patients.
The retrospective analysis was performed over a period of two years.
In 11/61 patients with active tuberculosis (18.0%) the test result was <0.35 IU/mL, resulting in a sensitivity of 0.82.
We recommend establishing a new cut-off value for the differential diagnosis of active tuberculosis assessed by prospective clinical studies and in various regions with high and low prevalence of tuberculosis.
American Psychological Association (APA)
Vesenbeckh, Silvan M.& Schönfeld, Nicolas& Mauch, Harald& Bergmann, Thorsten& Wagner, Sonja& Bauer, Torsten T.…[et al.]. 2012. The Use of Interferon Gamma Release Assays in the Diagnosis of Active Tuberculosis. Tuberculosis Research and Treatment،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-497275
Modern Language Association (MLA)
Vesenbeckh, Silvan M.…[et al.]. The Use of Interferon Gamma Release Assays in the Diagnosis of Active Tuberculosis. Tuberculosis Research and Treatment No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-497275
American Medical Association (AMA)
Vesenbeckh, Silvan M.& Schönfeld, Nicolas& Mauch, Harald& Bergmann, Thorsten& Wagner, Sonja& Bauer, Torsten T.…[et al.]. The Use of Interferon Gamma Release Assays in the Diagnosis of Active Tuberculosis. Tuberculosis Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-497275
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497275