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Amino-Functionalized Silica Nanoparticles : In Vitro Evaluation for Targeted Delivery and Therapy of Pancreatic Cancer
Joint Authors
Kardys, Abbey Y.
Bharali, Dhruba J.
Mousa, Shaker A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Abstract EN
We report a method of synthesis and optimization of amino-functionalized silica nanoparticles (SiNPs) and their in vitro evaluation as targeted delivery vehicles for the potential treatment of pancreatic cancer.
SiNPs can efficiently encapsulate doxorubicin and can be attached to a targeting moiety such as anti-Claudin-4 (CLN4).
The preferential uptake in pancreatic cancer cells, where CLN4 is overexpressed, of SiNPs when conjugated to CLN4 antibody (compared to nonconjugated SiNPs) was confirmed by confocal microscopy.
SiNPs encapsulating doxorubicin had greater efficacy in MTT assays than free doxorubicin, and when conjugated to CLN4, the efficacy was dramatically increased (at 1 μM).
No apparent carrier toxicity was observed when void SiNPs were used.
SiNPs carrying a chemotherapeutic drug have the potential to be used as a targeted therapy for lethal cancers, such as pancreatic cancer.
Also, incorporation of fluorescent probes in these SiNPs creates the possibility of their use as an imaging probe for diagnostic purposes.
American Psychological Association (APA)
Kardys, Abbey Y.& Bharali, Dhruba J.& Mousa, Shaker A.. 2013. Amino-Functionalized Silica Nanoparticles : In Vitro Evaluation for Targeted Delivery and Therapy of Pancreatic Cancer. Journal of Nanotechnology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-497276
Modern Language Association (MLA)
Kardys, Abbey Y.…[et al.]. Amino-Functionalized Silica Nanoparticles : In Vitro Evaluation for Targeted Delivery and Therapy of Pancreatic Cancer. Journal of Nanotechnology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-497276
American Medical Association (AMA)
Kardys, Abbey Y.& Bharali, Dhruba J.& Mousa, Shaker A.. Amino-Functionalized Silica Nanoparticles : In Vitro Evaluation for Targeted Delivery and Therapy of Pancreatic Cancer. Journal of Nanotechnology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-497276
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497276