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Simple Atomic Absorption Spectroscopic and Spectrophotometric Methods for Determination of Pioglitazone Hydrochloride and Carvedilol in Pharmaceutical Dosage Forms
Joint Authors
Abdelmonem, Afaf A.
Hashem, Hisham
Ragab, Gamal H.
Bahgat, Eman A.
Source
International Journal of Spectroscopy
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
This study represents simple atomic absorption spectroscopic and spectrophotometric methods for determination of pioglitazone hydrochloride (PGZ-HCl) and carvedilol (CRV) based on formation of ion-pair associates between drugs and inorganic complex, bismuth(III) tetraiodide (Method A) and between drugs and organic acidic dyes, fast green and orange G (Method B).
Method A is based on formation of ion-pair associate between drugs and bismuth(III) tetraiodide in acidic medium to form orange-red ion-pair associates, which can be quantitatively determined by two different procedures.
The formed ion-pair associate is extracted by methylene chloride, dissolved in acetone, dried, and then decomposed by hydrochloric acid, and bismuth content is determined by direct atomic absorption spectrometric technique (Procedure 1) or extracted by methylene chloride, dissolved in acetone, and quantified spectrophotometrically at 490 nm (Procedure 2).
Method B is based on formation of ion-pair associate between drugs and either fast green dye or orange G dye in acidic medium to form ion-pair associates.
The formed ion-pair associate is extracted by methylene chloride and quantified spectrophotometrically at 630 nm (for fast green dye method) or 498 nm (for orange G dye method).
Optimal experimental conditions have been studied.
Both methods are applied for determination of the drugs in tablets without interference.
American Psychological Association (APA)
Abdelmonem, Afaf A.& Ragab, Gamal H.& Hashem, Hisham& Bahgat, Eman A.. 2014. Simple Atomic Absorption Spectroscopic and Spectrophotometric Methods for Determination of Pioglitazone Hydrochloride and Carvedilol in Pharmaceutical Dosage Forms. International Journal of Spectroscopy،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-497286
Modern Language Association (MLA)
Abdelmonem, Afaf A.…[et al.]. Simple Atomic Absorption Spectroscopic and Spectrophotometric Methods for Determination of Pioglitazone Hydrochloride and Carvedilol in Pharmaceutical Dosage Forms. International Journal of Spectroscopy No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-497286
American Medical Association (AMA)
Abdelmonem, Afaf A.& Ragab, Gamal H.& Hashem, Hisham& Bahgat, Eman A.. Simple Atomic Absorption Spectroscopic and Spectrophotometric Methods for Determination of Pioglitazone Hydrochloride and Carvedilol in Pharmaceutical Dosage Forms. International Journal of Spectroscopy. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-497286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497286