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Proanthocyanidin Attenuation of Oxidative Stress and NF-κB Protects Apolipoprotein E-Deficient Mice against Diabetic Nephropathy
Joint Authors
El Rabey, Haddad A.
Sayed, Ahmed Amir Radwan
al-Malki, Abdulrahman L.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hyperlipidemia and hyperglycemia result in oxidative stress and play a major role in the development of diabetic nephropathy (DN).
We explored the effects of proanthocyanidin (PA) on the induction and progression of DN in apolipoprotein E-deficient mice.
Diabetes Mellitus was induced in ten-week-old male apoE−/−mice using streptozotocin (STZ).
Mice were fed with a high-fat diet in presence or absence of PA.
PA treatment significantly reduced the high cholesterol levels, restored renal functions, and reduced albuminuria in the PA-treated diabetic mice compared with the diabetic untreated mice.
In addition, the glomerular mesangial expansion in the diabetic mice was attenuated as a result of PA supplementation.
Moreover, PA treatment restored the elevated levels of MDA and CML and the reduced activity of SOD and GSH in the diabetic mice.
Furthermore, PA feeding reduced the activation and translocation of NF-κB to the nucleus compared with the diabetic untreated animals.
Reduction of NF-κB activation resulted in the attenuation of the expression of IL-6, TGFβ, and RAGE which protected PA-treated mice against DN.
The renoprotective effects of PA were found to be time independent regardless of whether the dietary feeding with PA was started pre-, co-, or post-STZ injection.
In conclusion, part of the beneficial effects of PA includes the disruption of the detrimental AGE-RAGE-NFκB pathways.
American Psychological Association (APA)
al-Malki, Abdulrahman L.& Sayed, Ahmed Amir Radwan& El Rabey, Haddad A.. 2013. Proanthocyanidin Attenuation of Oxidative Stress and NF-κB Protects Apolipoprotein E-Deficient Mice against Diabetic Nephropathy. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-497336
Modern Language Association (MLA)
al-Malki, Abdulrahman L.…[et al.]. Proanthocyanidin Attenuation of Oxidative Stress and NF-κB Protects Apolipoprotein E-Deficient Mice against Diabetic Nephropathy. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-497336
American Medical Association (AMA)
al-Malki, Abdulrahman L.& Sayed, Ahmed Amir Radwan& El Rabey, Haddad A.. Proanthocyanidin Attenuation of Oxidative Stress and NF-κB Protects Apolipoprotein E-Deficient Mice against Diabetic Nephropathy. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-497336
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497336