The Extract of Litsea japonica Reduced the Development of Diabetic Nephropathy via the Inhibition of Advanced Glycation End Products Accumulation in dbdb Mice

Joint Authors

Kim, Chan-Sik
Kim, Joo Hwan
Lee, Yun Mi
Jo, Kyuhyung
Shin, So Dam
Sohn, Eun Jin
Kim, Jin Sook
Kim, Junghyun

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-05-27

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Medicine

Abstract EN

Increasing evidence indicates that advanced glycation end products (AGEs) contribute to the pathogenesis of diabetic nephropathy.

The aim of this study was to investigate the protective effect of L.

japonica extract (LJE) against renal damage in the db/db mouse.

LJE (100 or 250 mg/kg per day) was given to diabetic mice for 12 weeks.

Body weight, blood glucose levels, glycated hemoglobin (HbA1c) levels, and proteinuria were examined.

In in vitro assay of the inhibition of AGE formation, immunohistochemical analysis of podocyte loss and AGE accumulations were performed.

In 20-week-old db/db mice, severe hyperglycemia developed, and proteinuria was significantly increased.

Diabetes induced markedly morphological alterations to the renal glomerular cells.

AGE accumulations and podocyte loss were detected in renal glomeruli.

LJE treatment significantly reduced proteinuria and AGE accumulations in diabetic mice.

Moreover, the loss of nephrin, an important slit diaphragm component in the kidneys, was restored by LJE treatment.

Our studies suggest that LJE might be beneficial for the treatment of diabetic nephropathy.

The ability of LJE to attenuate proteinuria and podocyte dysfunction may be mediated by the inhibition of AGE accumulation in the context of diabetic nephropathy in db/db mice.

American Psychological Association (APA)

Sohn, Eun Jin& Kim, Junghyun& Kim, Chan-Sik& Lee, Yun Mi& Jo, Kyuhyung& Shin, So Dam…[et al.]. 2013. The Extract of Litsea japonica Reduced the Development of Diabetic Nephropathy via the Inhibition of Advanced Glycation End Products Accumulation in dbdb Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-497340

Modern Language Association (MLA)

Sohn, Eun Jin…[et al.]. The Extract of Litsea japonica Reduced the Development of Diabetic Nephropathy via the Inhibition of Advanced Glycation End Products Accumulation in dbdb Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-497340

American Medical Association (AMA)

Sohn, Eun Jin& Kim, Junghyun& Kim, Chan-Sik& Lee, Yun Mi& Jo, Kyuhyung& Shin, So Dam…[et al.]. The Extract of Litsea japonica Reduced the Development of Diabetic Nephropathy via the Inhibition of Advanced Glycation End Products Accumulation in dbdb Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-497340

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-497340