The Extract of Litsea japonica Reduced the Development of Diabetic Nephropathy via the Inhibition of Advanced Glycation End Products Accumulation in dbdb Mice
Joint Authors
Kim, Chan-Sik
Kim, Joo Hwan
Lee, Yun Mi
Jo, Kyuhyung
Shin, So Dam
Sohn, Eun Jin
Kim, Jin Sook
Kim, Junghyun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Increasing evidence indicates that advanced glycation end products (AGEs) contribute to the pathogenesis of diabetic nephropathy.
The aim of this study was to investigate the protective effect of L.
japonica extract (LJE) against renal damage in the db/db mouse.
LJE (100 or 250 mg/kg per day) was given to diabetic mice for 12 weeks.
Body weight, blood glucose levels, glycated hemoglobin (HbA1c) levels, and proteinuria were examined.
In in vitro assay of the inhibition of AGE formation, immunohistochemical analysis of podocyte loss and AGE accumulations were performed.
In 20-week-old db/db mice, severe hyperglycemia developed, and proteinuria was significantly increased.
Diabetes induced markedly morphological alterations to the renal glomerular cells.
AGE accumulations and podocyte loss were detected in renal glomeruli.
LJE treatment significantly reduced proteinuria and AGE accumulations in diabetic mice.
Moreover, the loss of nephrin, an important slit diaphragm component in the kidneys, was restored by LJE treatment.
Our studies suggest that LJE might be beneficial for the treatment of diabetic nephropathy.
The ability of LJE to attenuate proteinuria and podocyte dysfunction may be mediated by the inhibition of AGE accumulation in the context of diabetic nephropathy in db/db mice.
American Psychological Association (APA)
Sohn, Eun Jin& Kim, Junghyun& Kim, Chan-Sik& Lee, Yun Mi& Jo, Kyuhyung& Shin, So Dam…[et al.]. 2013. The Extract of Litsea japonica Reduced the Development of Diabetic Nephropathy via the Inhibition of Advanced Glycation End Products Accumulation in dbdb Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-497340
Modern Language Association (MLA)
Sohn, Eun Jin…[et al.]. The Extract of Litsea japonica Reduced the Development of Diabetic Nephropathy via the Inhibition of Advanced Glycation End Products Accumulation in dbdb Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-497340
American Medical Association (AMA)
Sohn, Eun Jin& Kim, Junghyun& Kim, Chan-Sik& Lee, Yun Mi& Jo, Kyuhyung& Shin, So Dam…[et al.]. The Extract of Litsea japonica Reduced the Development of Diabetic Nephropathy via the Inhibition of Advanced Glycation End Products Accumulation in dbdb Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-497340
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497340