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Long-Term Results after Treatment of Very Low-, Low-, and High-Risk Thyroid Cancers in a Combined Setting of Thyroidectomy and Radio Ablation Therapy in Euthyroidism
Joint Authors
Winkler, Michael
Klempnauer, Juergen
Schrem, Harald
Scheumann, Georg F. W.
Emmanouilidis, Nikos
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Differentiated thyroid cancer treatment usually consists of thyroidectomy and radio ablation in hypothyroidism 4-6 weeks after surgery.
Replacing hypothyroidism by recombinant human thyroid stimulating hormone can facilitate radio ablation in euthyroidism within one week after surgery.
The outcome of this approach was investigated.
Methods.
This is a prospective randomized trial to compare thyroidectomy and radio ablation within a few days after preconditioning with recombinant human thyroid stimulating hormone versus thyroidectomy and radio ablation separated by four weeks of L-T4 withdrawal.
Tumors were graded into very low-, low- , or high-risk tumors.
Recurrence-free survival was confirmed at follow-up controls by neck ultrasound and serum thyroglobulin.
Suspected tumor recurrence was treated by additional radio ablation or surgery.
Quality-of-life questionnaires with additional evaluation of job performance and sick-leave time were used in all patients.
Results.
Radio ablation in euthyroidism in quick succession after thyroidectomy did not lead to higher tumor recurrence rates of differentiated thyroid cancers in any risk category and was significantly advantageous with respect to quality-of-life (P<0.001), sick-leave time (P<0.001), and job performance (P=0.002).
Conclusion.
Recombinant human thyroid stimulating hormone can be used safely and with good efficacy to allow radio ablation under sustained euthyroidism within one week after thyroidectomy.
American Psychological Association (APA)
Emmanouilidis, Nikos& Schrem, Harald& Winkler, Michael& Klempnauer, Juergen& Scheumann, Georg F. W.. 2013. Long-Term Results after Treatment of Very Low-, Low-, and High-Risk Thyroid Cancers in a Combined Setting of Thyroidectomy and Radio Ablation Therapy in Euthyroidism. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-497345
Modern Language Association (MLA)
Emmanouilidis, Nikos…[et al.]. Long-Term Results after Treatment of Very Low-, Low-, and High-Risk Thyroid Cancers in a Combined Setting of Thyroidectomy and Radio Ablation Therapy in Euthyroidism. International Journal of Endocrinology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-497345
American Medical Association (AMA)
Emmanouilidis, Nikos& Schrem, Harald& Winkler, Michael& Klempnauer, Juergen& Scheumann, Georg F. W.. Long-Term Results after Treatment of Very Low-, Low-, and High-Risk Thyroid Cancers in a Combined Setting of Thyroidectomy and Radio Ablation Therapy in Euthyroidism. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-497345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497345