Efficacy and Tolerability of a Combined MoxifloxacinDexamethasone Formulation for Topical Prophylaxis in Phacoemulsification : An Open-Label Single-Arm Clinical Trial
Joint Authors
Tayengco, Tommee Lynne G.
Espiritu, Cesar Ramon G.
Sy, Mary Ellen A.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
The use of a fixed-combination antibiotic corticosteroid for infection prophylaxis in Asian patients undergoing phacoemulsification has not been reported.
Methods.
A 15-day, open-label, single-arm trial of 64 patients for phacoemulsification with intraocular lens (IOL) implantation is described.
Patients applied moxifloxacin 0.5%/dexamethasone 0.1% (Vigadexa) eye drops four times daily before and until 15 days after surgery.
Anterior chamber (AC) reaction, visual acuity, ocular pain and signs, and intraocular pressure (IOP) were assessed at baseline and on postoperative days 1, 3, 8, and 15.
Results.
At day 15, 55 (91.7%) patients scored 0 (<5 cells) in AC reaction.
No surgery-related infection occurred.
Mean best-corrected visual acuity improved 0.5 logMAR from baseline to 0.0 logMAR (P<.0001).
Mean IOP remained at 12-13 mm Hg over the 15-day treatment.
Only 2 patients (3.1%) reported minimum ocular pain.
Two (3.1%) patients were shifted to prednisolone acetate for severe inflammation.
At the end of the study period, 8.3% were given fluorometholone for 1 week for AC reaction grade >0.
No drug-related adverse event was reported.
Conclusion.
Following phacoemulsification and IOL implantation, the topical combination moxifloxacin 0.5%/dexamethasone 0.1% was effective in preventing infection and controlling inflammation and was well tolerated.
American Psychological Association (APA)
Espiritu, Cesar Ramon G.& Sy, Mary Ellen A.& Tayengco, Tommee Lynne G.. 2011. Efficacy and Tolerability of a Combined MoxifloxacinDexamethasone Formulation for Topical Prophylaxis in Phacoemulsification : An Open-Label Single-Arm Clinical Trial. Journal of Ophthalmology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-497354
Modern Language Association (MLA)
Espiritu, Cesar Ramon G.…[et al.]. Efficacy and Tolerability of a Combined MoxifloxacinDexamethasone Formulation for Topical Prophylaxis in Phacoemulsification : An Open-Label Single-Arm Clinical Trial. Journal of Ophthalmology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-497354
American Medical Association (AMA)
Espiritu, Cesar Ramon G.& Sy, Mary Ellen A.& Tayengco, Tommee Lynne G.. Efficacy and Tolerability of a Combined MoxifloxacinDexamethasone Formulation for Topical Prophylaxis in Phacoemulsification : An Open-Label Single-Arm Clinical Trial. Journal of Ophthalmology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-497354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497354