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Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavirr-Containing Antiretroviral Therapy in South Africa
Joint Authors
Mellors, John W.
Sanne, Ian
Stevens, Wendy
Wallis, Carole L.
Venter, Willem D. F.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Limited data exist on HIV-1 drug resistance patterns in South Africa following second-line protease-inhibitor containing regimen failure.
This study examined drug resistance patterns emerging in 75 HIV-1 infected adults experiencing virologic failure on a second-line regimen containing 2 NRTI and lopinavir/ritonavir.
Ninety six percent of patients (n=72) were infected with HIV-1 subtype C, two patients were infected with HIV-1 subtype D and one with HIV-1 subtype A1.
Thirty nine percent (n=29) of patients had no resistance mutations in protease or reverse transcriptase suggesting that medication non-adherence was a major factor contributing to failure.
Major lopinavir resistance mutations were infrequent (5 of 75; 7%), indicating that drug resistance is not the main barrier to future viral suppression.
American Psychological Association (APA)
Wallis, Carole L.& Mellors, John W.& Venter, Willem D. F.& Sanne, Ian& Stevens, Wendy. 2010. Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavirr-Containing Antiretroviral Therapy in South Africa. AIDS Research and Treatment،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-497360
Modern Language Association (MLA)
Wallis, Carole L.…[et al.]. Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavirr-Containing Antiretroviral Therapy in South Africa. AIDS Research and Treatment No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-497360
American Medical Association (AMA)
Wallis, Carole L.& Mellors, John W.& Venter, Willem D. F.& Sanne, Ian& Stevens, Wendy. Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavirr-Containing Antiretroviral Therapy in South Africa. AIDS Research and Treatment. 2010. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-497360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497360