![](/images/graphics-bg.png)
M-CSF and GM-CSF Regulation of STAT5 Activation and DNA Binding in Myeloid Cell Differentiation is Disrupted in Nonobese Diabetic Mice
Joint Authors
Litherland, S. A.
Elf, J.
Garrigan, E.
Rumore-Maton, B.
Stutevoss, B.
Seydel, F.
Belkin, N.
Source
Clinical and Developmental Immunology
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-01-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Defects in macrophage colony-stimulating factor (M-CSF) signaling disrupt myeloid cell differentiation in nonobese diabetic (NOD) mice, blocking myeloid maturation into tolerogenic antigen-presenting cells (APCs).
In the absence of M-CSF signaling, NOD myeloid cells have abnormally high granulocyte macrophage colony-stimulating factor (GM-CSF) expression, and as a result, persistent activation of signal transducer/activator of transcription 5 (STAT5).
Persistent STAT5 phosphorylation found in NOD macrophages is not affected by inhibiting GM-CSF.
However, STAT5 phosphorylation in NOD bone marrow cells is diminished if GM-CSF signaling is blocked.
Moreover, if M-CSF signaling is inhibited, GM-CSF stimulation in vitro can promote STAT5 phosphorylation in nonautoimmune C57BL/6 mouse bone marrow cultures to levels seen in the NOD.
These findings suggest that excessive GM-CSF production in the NOD bone marrow may interfere with the temporal sequence of GM-CSF and M-CSF signaling needed to mediate normal STAT5 function in myeloid cell differentiation gene regulation.
American Psychological Association (APA)
Rumore-Maton, B.& Elf, J.& Belkin, N.& Stutevoss, B.& Seydel, F.& Garrigan, E.…[et al.]. 2009. M-CSF and GM-CSF Regulation of STAT5 Activation and DNA Binding in Myeloid Cell Differentiation is Disrupted in Nonobese Diabetic Mice. Clinical and Developmental Immunology،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-497373
Modern Language Association (MLA)
Rumore-Maton, B.…[et al.]. M-CSF and GM-CSF Regulation of STAT5 Activation and DNA Binding in Myeloid Cell Differentiation is Disrupted in Nonobese Diabetic Mice. Clinical and Developmental Immunology No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-497373
American Medical Association (AMA)
Rumore-Maton, B.& Elf, J.& Belkin, N.& Stutevoss, B.& Seydel, F.& Garrigan, E.…[et al.]. M-CSF and GM-CSF Regulation of STAT5 Activation and DNA Binding in Myeloid Cell Differentiation is Disrupted in Nonobese Diabetic Mice. Clinical and Developmental Immunology. 2009. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-497373
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497373