Exposure to Mebendazole and Pyrvinium during Pregnancy : A Danish Nationwide Cohort Study
Joint Authors
Andersen, Jon Trærup
Torp-Pedersen, A.
Torp-Pedersen, C.
Broedbaek, K.
Jimenez-Solem, E.
Poulsen, Henrik Enghusen
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
Families with children are frequently exposed to pinworm infection and treatment involves the whole family.
Information on consequences of exposure during, pregnancy is limited.
The aim of this study was to investigate the exposure to pyrvinium and mebendazole before, during, and after pregnancy in a Danish nationwide cohort.
Methods.
From nationwide administrative registers, we identified 718, 900 births in Denmark between January 1997 and December 2007 as well as maternal prescription data of anthelmintics and maternal characteristics.
Redemption of a prescription for pyrvinium or mebendazole was used to identify exposure.
Results.
4715 women redeemed a prescription for pyrvinium or mebendazole during pregnancy; 1606 for pyrvinium, 2575 for mebendazole, and 534 for both drugs.
Having >2 children compared to having no previous children was associated with exposure to pyrvinium (OR: 7.1, 95% CI: 5.8–8.7) and mebendazole (OR: 20.8, 95% CI: 17.3–24.9).
Conclusion.
4715 pregnant women redeemed a prescription for either mebendazole or pyrvinium.
We believe the exposure to be even higher since pyrvinium is also sold over-the-counter.
Limited information on birth outcomes is available at present time, and considering the number of exposed pregnancies, we recommend that studies are to be undertaken to assess the safety of pyrvinium and mebendazole during pregnancy.
American Psychological Association (APA)
Torp-Pedersen, A.& Jimenez-Solem, E.& Andersen, Jon Trærup& Broedbaek, K.& Torp-Pedersen, C.& Poulsen, Henrik Enghusen. 2012. Exposure to Mebendazole and Pyrvinium during Pregnancy : A Danish Nationwide Cohort Study. Infectious Diseases in Obstetrics and Gynecology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-497376
Modern Language Association (MLA)
Torp-Pedersen, A.…[et al.]. Exposure to Mebendazole and Pyrvinium during Pregnancy : A Danish Nationwide Cohort Study. Infectious Diseases in Obstetrics and Gynecology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-497376
American Medical Association (AMA)
Torp-Pedersen, A.& Jimenez-Solem, E.& Andersen, Jon Trærup& Broedbaek, K.& Torp-Pedersen, C.& Poulsen, Henrik Enghusen. Exposure to Mebendazole and Pyrvinium during Pregnancy : A Danish Nationwide Cohort Study. Infectious Diseases in Obstetrics and Gynecology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-497376
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497376