Mannan-Binding Lectin Levels and Activity Are Not Altered in Atopic Dermatitis Patients with a History of Eczema Herpeticum
Joint Authors
Bankova, Lora G.
De Benedetto, Anna
Bundy, Kemp W.
McGirt, Laura Y.
Wollenberg, Andreas
Beck, Lisa A.
Source
Dermatology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-10
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Background.
Eczema herpeticum (EH) is a potentially serious, systemic complication in subjects with atopic dermatitis (AD) caused by herpes simplex virus (HSV).
The innate immune dysregulation that predisposes these subjects to cutaneous viral infections is not well understood.
We tested the hypothesis that defects in mannan-binding lectin (MBL) may be associated with an increased risk of EH.
Methods.
We evaluated serum MBL levels and functional activity in 13 AD subjects with a history of EH (EH+) and 21 AD subjects with no history of EH (EH−).
MBL levels were detected by enzyme immunoassay.
MBL pathway functional activity was evaluated by determining MBL C4b deposition capacity.
Results.
We found no statistical difference in MBL serum levels or function between EH+ and EH− groups.
Conclusion.
Considering the limitations of this study (e.g., small samples size) our findings suggest that MBL defects do not play a role in EH.
American Psychological Association (APA)
Bundy, Kemp W.& McGirt, Laura Y.& Bankova, Lora G.& Wollenberg, Andreas& Beck, Lisa A.& De Benedetto, Anna. 2011. Mannan-Binding Lectin Levels and Activity Are Not Altered in Atopic Dermatitis Patients with a History of Eczema Herpeticum. Dermatology Research and Practice،Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-497380
Modern Language Association (MLA)
Bundy, Kemp W.…[et al.]. Mannan-Binding Lectin Levels and Activity Are Not Altered in Atopic Dermatitis Patients with a History of Eczema Herpeticum. Dermatology Research and Practice No. 2011 (2011), pp.1-3.
https://search.emarefa.net/detail/BIM-497380
American Medical Association (AMA)
Bundy, Kemp W.& McGirt, Laura Y.& Bankova, Lora G.& Wollenberg, Andreas& Beck, Lisa A.& De Benedetto, Anna. Mannan-Binding Lectin Levels and Activity Are Not Altered in Atopic Dermatitis Patients with a History of Eczema Herpeticum. Dermatology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-497380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497380