Staging of Alzheimer's Pathology in Triple Transgenic Mice : A Light and Electron Microscopic Analysis
Joint Authors
Vana, Laurel
Mufson, Elliott J.
Oh, Kwang-Jin
Lagalwar, Sarita
Perez, Sylvia E.
Binder, Lester
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-15
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
The age-related pathological cascade underlying intraneuronal tau formation in 3xTg-AD mice, which harbor the human APPSwe, PS1M126V , and TauP301L gene mutations, remains unclear.
At 3 weeks of age, AT180, Alz50, MC1, AT8, and PHF-1 intraneuronal immunoreactivity appeared in the amygdala and hippocampus and at later ages in the cortex of 3xTg-AD mice.
AT8 and PHF-1 staining was fixation dependent in young mutant mice.
6E10 staining was seen at all ages.
Fluorescent immunomicroscopy revealed CA1 neurons dual stained for 6E10 and Alz50 and single Alz50 immunoreactive neurons in the subiculum at 3 weeks and continuing to 20 months.
Although electron microscopy confirmed intraneuronal cytoplasmic Alz50, AT8, and 6E10 reaction product in younger 3xTg-AD mice, straight filaments appeared at 23 months of age in female mice.
The present data suggest that other age-related biochemical mechanisms in addition to early intraneuronal accumulation of 6E10 and tau underlie the formation of tau filaments in 3xTg-AD mice.
American Psychological Association (APA)
Oh, Kwang-Jin& Perez, Sylvia E.& Lagalwar, Sarita& Vana, Laurel& Binder, Lester& Mufson, Elliott J.. 2010. Staging of Alzheimer's Pathology in Triple Transgenic Mice : A Light and Electron Microscopic Analysis. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-24.
https://search.emarefa.net/detail/BIM-497383
Modern Language Association (MLA)
Oh, Kwang-Jin…[et al.]. Staging of Alzheimer's Pathology in Triple Transgenic Mice : A Light and Electron Microscopic Analysis. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-24.
https://search.emarefa.net/detail/BIM-497383
American Medical Association (AMA)
Oh, Kwang-Jin& Perez, Sylvia E.& Lagalwar, Sarita& Vana, Laurel& Binder, Lester& Mufson, Elliott J.. Staging of Alzheimer's Pathology in Triple Transgenic Mice : A Light and Electron Microscopic Analysis. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-24.
https://search.emarefa.net/detail/BIM-497383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497383