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Assessment of Minimal Residual Disease in Ewing Sarcoma
Joint Authors
Sumegi, Janos
Wagner, Lars M.
Smolarek, Teresa A.
Marmer, Daniel
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Advances in molecular pathology now allow for identification of rare tumor cells in cancer patients.
Identification of this minimal residual disease is particularly relevant for Ewing sarcoma, given the potential for recurrence even after complete remission is achieved.
Using RT-PCR to detect specific tumor-associated fusion transcripts, otherwise occult tumor cells are found in blood or bone marrow in 20–30% of Ewing sarcoma patients, and their presence is associated with inferior outcomes.
Although RT-PCR has excellent sensitivity and specificity for identifying tumor cells, technical challenges may limit its widespread applicability.
The use of flow cytometry to identify tumor-specific antigens is a recently described method that may circumvent these difficulties.
In this manuscript, we compare the advantages and drawbacks of these approaches, present data on a third method using fluorescent in situ hybridization, and discuss issues affecting the further development of these strategies.
American Psychological Association (APA)
Wagner, Lars M.& Smolarek, Teresa A.& Sumegi, Janos& Marmer, Daniel. 2012. Assessment of Minimal Residual Disease in Ewing Sarcoma. Sarcoma،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-497386
Modern Language Association (MLA)
Wagner, Lars M.…[et al.]. Assessment of Minimal Residual Disease in Ewing Sarcoma. Sarcoma No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-497386
American Medical Association (AMA)
Wagner, Lars M.& Smolarek, Teresa A.& Sumegi, Janos& Marmer, Daniel. Assessment of Minimal Residual Disease in Ewing Sarcoma. Sarcoma. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-497386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497386