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Development and Evaluation of Microemulsions for Transdermal Delivery of Insulin
Joint Authors
Sen, Suma Oomen
Sen, Kalyan Kumar
Nayak, Amit Kumar
Malakar, Jadupati
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Insulin-loaded microemulsions for transdermal delivery were developed using isopropyl myristate or oleic acid as the oil phase, Tween 80 as the surfactant, and isopropyl alcohol as the cosurfactant.
The pseudoternary phase diagrams were constructed to determine the composition of microemulsions.
The insulin permeation flux of microemulsions containing oleic acid as oil phase through excised mouse skin and goat skin was comparatively greater than that of microemulsions containing isopropyl myristate as oil phase.
The insulin-loaded microemulsion containing 10% oleic acid, 38% aqueous phase, and 50% surfactant phase with 2% dimethyl sulfoxide (DMSO) as permeation enhancer showed maximum permeation flux (4.93 ± 0.12 μg/cm2/hour) through goat skin.
The in vitro insulin permeation from these microemulsions was found to follow the Korsmeyer-Peppas model (R2=0.923 to 0.973) over a period of 24 hours with non-Fickian, “anomalous” mechanism.
Together these preliminary data indicate the promise of microemulsions for transdermal delivery of insulin.
American Psychological Association (APA)
Malakar, Jadupati& Sen, Suma Oomen& Nayak, Amit Kumar& Sen, Kalyan Kumar. 2011. Development and Evaluation of Microemulsions for Transdermal Delivery of Insulin. ISRN Pharmaceutics،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-497390
Modern Language Association (MLA)
Malakar, Jadupati…[et al.]. Development and Evaluation of Microemulsions for Transdermal Delivery of Insulin. ISRN Pharmaceutics No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-497390
American Medical Association (AMA)
Malakar, Jadupati& Sen, Suma Oomen& Nayak, Amit Kumar& Sen, Kalyan Kumar. Development and Evaluation of Microemulsions for Transdermal Delivery of Insulin. ISRN Pharmaceutics. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-497390
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497390