Interferon Regulatory Factor 5 in the Pathogenesis of Systemic Lupus Erythematosus
Joint Authors
Cham, Candace M.
Ko, Kichul
Niewold, Timothy B.
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple genetic risk factors, high levels of interferon alpha (IFN-α), and the production of autoantibodies against components of the cell nucleus.
Interferon regulatory factor 5 (IRF5) is a transcription factor which induces the transcription of IFN-α and other cytokines, and genetic variants of IRF5 have been strongly linked to SLE pathogenesis.
IRF5 functions downstream of Toll-like receptors and other microbial pattern-recognition receptors, and immune complexes made up of SLE-associated autoantibodies seem to function as a chronic endogenous stimulus to this pathway.
In this paper, we discuss the physiologic role of IRF5 in immune defense and the ways in which IRF5 variants may contribute to the pathogenesis of human SLE.
Recent data regarding the role of IRF5 in both serologic autoimmunity and the overproduction of IFN-α in human SLE are summarized.
These data support a model in which SLE-risk variants of IRF5 participate in a “feed-forward” mechanism, predisposing to SLE-associated autoantibody formation, and subsequently facilitating IFN-α production downstream of Toll-like receptors stimulated by immune complexes composed of these autoantibodies.
American Psychological Association (APA)
Cham, Candace M.& Ko, Kichul& Niewold, Timothy B.. 2012. Interferon Regulatory Factor 5 in the Pathogenesis of Systemic Lupus Erythematosus. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-497415
Modern Language Association (MLA)
Cham, Candace M.…[et al.]. Interferon Regulatory Factor 5 in the Pathogenesis of Systemic Lupus Erythematosus. Clinical and Developmental Immunology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-497415
American Medical Association (AMA)
Cham, Candace M.& Ko, Kichul& Niewold, Timothy B.. Interferon Regulatory Factor 5 in the Pathogenesis of Systemic Lupus Erythematosus. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-497415
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497415