Evidence for the Role of B Cells and Immunoglobulins in the Pathogenesis of Multiple Sclerosis
Joint Authors
Winters, Jeffrey L.
Warrington, Arthur E.
Bieber, Allan J.
Keegan, B. Mark
Astapenko, David
Rodriguez, Moses
Wootla, Bharath
Denic, Aleksandar
Source
Neurology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-22
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The pathogenesis of multiple sclerosis (MS) remains elusive.
Recent reports advocate greater involvement of B cells and immunoglobulins in the initiation and propagation of MS lesions at different stages of their ontogeny.
The key role of B cells and immunoglobulins in pathogenesis was initially identified by studies in which patients whose fulminant attacks of demyelination did not respond to steroids experienced remarkable functional improvement following plasma exchange.
The positive response to Rituximab in Phase II clinical trials of relapsing-remitting MS confirms the role of B cells.
The critical question is how B cells contribute to MS.
In this paper, we discuss both the deleterious and the beneficial roles of B cells and immunoglobulins in MS lesions.
We provide alternative hypotheses to explain both damaging and protective antibody responses.
American Psychological Association (APA)
Wootla, Bharath& Denic, Aleksandar& Keegan, B. Mark& Winters, Jeffrey L.& Astapenko, David& Warrington, Arthur E.…[et al.]. 2011. Evidence for the Role of B Cells and Immunoglobulins in the Pathogenesis of Multiple Sclerosis. Neurology Research International،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-497442
Modern Language Association (MLA)
Wootla, Bharath…[et al.]. Evidence for the Role of B Cells and Immunoglobulins in the Pathogenesis of Multiple Sclerosis. Neurology Research International No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-497442
American Medical Association (AMA)
Wootla, Bharath& Denic, Aleksandar& Keegan, B. Mark& Winters, Jeffrey L.& Astapenko, David& Warrington, Arthur E.…[et al.]. Evidence for the Role of B Cells and Immunoglobulins in the Pathogenesis of Multiple Sclerosis. Neurology Research International. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-497442
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497442